Chiral AuI - and AuIII -Isothiourea Complexes: Synthesis, Characterization and Application

Danila Gasperini, Mark D. Greenhalgh, Rehan Imad, Shezaib Siddiqui, Anum Malik, Fizza Arshad, Muhammad Iqbal Choudhary, Abdullah M. Al-Majid, David B. Cordes, Alexandra M. Z. Slawin, Steven P. Nolan, Andrew D. Smith

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

During an investigation into the potential union of Lewis basic isothiourea organocatalysis and gold catalysis, the formation of gold-isothiourea complexes was observed. These novel gold complexes were formed in high yield and were found to be air- and moisture stable. A series of neutral and cationic chiral gold(I) and gold(III) complexes bearing enantiopure isothiourea ligands was therefore synthesized and fully characterized. The steric and electronic properties of the isothiourea ligands was assessed through calculation of their percent buried volume and the synthesis and analysis of novel iridium(I)-isothiourea carbonyl complexes. The novel gold(I)- and gold(III)-isothiourea complexes have been applied in preliminary catalytic and biological studies, and display promising preliminary levels of catalytic activity and potency towards cancerous cell lines and clinically relevant enzymes.
Original languageEnglish (US)
Pages (from-to)1064-1075
Number of pages12
JournalChemistry - A European Journal
Volume25
Issue number4
DOIs
StatePublished - Dec 21 2018
Externally publishedYes

Bibliographical note

KAUST Repository Item: Exported on 2021-03-11
Acknowledged KAUST grant number(s): OSR-2015-CCF-1974-03
Acknowledgements: A.D.S. thanks the Royal Society for a Wolfson Research Merit Award. We also thank the EPSRC UK National Mass Spectrometry Facility at Swansea University. S.P.N. thanks King Abdullah University of Science and Technology (Award No. OSR-2015-CCF-1974-03) and King Saud University for support via its DSFP program.
This publication acknowledges KAUST support, but has no KAUST affiliated authors.

ASJC Scopus subject areas

  • Chemistry(all)

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