Chemotherapeutic Evaluation of a Synthetic Tubulysin Analogue-Dendrimer Conjugate in C26 Tumor Bearing Mice

William C. Floyd; Gopal K. Datta; Shinichi Imamura; Heidi M. Kieler-Ferguson; Katherine Jerger; Andrew W. Patterson; Megan E. Fox; Francis C. Szoka; Jean M.J. Fréchet; Jonathan A. Ellman

doi:10.1002/cmdc.201000377

Chemotherapeutic Evaluation of a Synthetic Tubulysin Analogue-Dendrimer Conjugate in C26 Tumor Bearing Mice

William C. Floyd, Gopal K. Datta, Shinichi Imamura, Heidi M. Kieler-Ferguson, Katherine Jerger, Andrew W. Patterson, Megan E. Fox, Francis C. Szoka^*, Jean M.J. Fréchet, Jonathan A. Ellman

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Conjugate to ameliorate! Polymeric drug delivery using a synthetic tubulysin analogue in C26 tumor bearing mice is described. A single dose of this conjugate (shown) resulted in a 90 % increase in the average lifespan of the mice as compared to groups given a phosphate-buffered saline control or the free tubulysin analogue. Moreover, 37 % of the mice given the polymeric formulation were tumor free at the conclusion of the study.

Original language	English (US)
Pages (from-to)	49-53
Number of pages	5
Journal	ChemMedChem
Volume	6
Issue number	1
DOIs	https://doi.org/10.1002/cmdc.201000377
State	Published - Jan 3 2011

Keywords

Antitumor agents
Colon carcinoma
Dendrimers
Drug delivery
Tubulysins

ASJC Scopus subject areas

Drug Discovery
General Pharmacology, Toxicology and Pharmaceutics
Molecular Medicine
Biochemistry
Pharmacology
Organic Chemistry

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title = "Chemotherapeutic Evaluation of a Synthetic Tubulysin Analogue-Dendrimer Conjugate in C26 Tumor Bearing Mice",

abstract = "Conjugate to ameliorate! Polymeric drug delivery using a synthetic tubulysin analogue in C26 tumor bearing mice is described. A single dose of this conjugate (shown) resulted in a 90 % increase in the average lifespan of the mice as compared to groups given a phosphate-buffered saline control or the free tubulysin analogue. Moreover, 37 % of the mice given the polymeric formulation were tumor free at the conclusion of the study.",

keywords = "Antitumor agents, Colon carcinoma, Dendrimers, Drug delivery, Tubulysins",

author = "Floyd, {William C.} and Datta, {Gopal K.} and Shinichi Imamura and Kieler-Ferguson, {Heidi M.} and Katherine Jerger and Patterson, {Andrew W.} and Fox, {Megan E.} and Szoka, {Francis C.} and Fr{\'e}chet, {Jean M.J.} and Ellman, {Jonathan A.}",

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AU - Floyd, William C.

AU - Datta, Gopal K.

AU - Imamura, Shinichi

AU - Kieler-Ferguson, Heidi M.

AU - Jerger, Katherine

AU - Patterson, Andrew W.

AU - Fox, Megan E.

AU - Szoka, Francis C.

AU - Fréchet, Jean M.J.

AU - Ellman, Jonathan A.

PY - 2011/1/3

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AB - Conjugate to ameliorate! Polymeric drug delivery using a synthetic tubulysin analogue in C26 tumor bearing mice is described. A single dose of this conjugate (shown) resulted in a 90 % increase in the average lifespan of the mice as compared to groups given a phosphate-buffered saline control or the free tubulysin analogue. Moreover, 37 % of the mice given the polymeric formulation were tumor free at the conclusion of the study.

KW - Antitumor agents

KW - Colon carcinoma

KW - Dendrimers

KW - Drug delivery

KW - Tubulysins

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Chemotherapeutic Evaluation of a Synthetic Tubulysin Analogue-Dendrimer Conjugate in C26 Tumor Bearing Mice

Abstract

Keywords

ASJC Scopus subject areas

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