Chemical and Physical Approaches for Improved Biopharmaceutical Activity of Amphotericin B: Current and Future Prospective

Ajay Mahor, Devesh M. Sawant, Amit Kumar Goyal

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Over the last 50 years, the number of patients with mycotic infections has gradually in-creased. Amphotericin-B is a gold-standard drug used in serious systemic fungal infections. How-ever, limited solubility and permeability are challenging issues associated with Amphotericin-B. Chemical modification is one of the ways to get its broader applicability and improved physico-chemical properties. The review article provides a comprehensive overview of the chemical modification approach for investigating the mechanism of action, biological activity, bioavailability, and toxicity of Amphotericin B. Further, several drug delivery approaches have also been utilized to provide better therapeutic outcomes. This gives an overview of chemical approaches for exploring various factors associated with Amphotericin B and information on its drug delivery approaches for improved biopharmaceutical outcomes.
Original languageEnglish (US)
Pages (from-to)1571-1592
Number of pages22
JournalCurrent Topics in Medicinal Chemistry
Volume22
Issue number19
DOIs
StatePublished - Jul 1 2022
Externally publishedYes

Bibliographical note

Generated from Scopus record by KAUST IRTS on 2023-10-12

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