Characterization of piRNAs across postnatal development in mouse brain

Yanal Ghosheh; Loqmane Seridi; Tae Woo Ryu; Hazuki Takahashi; Valerio Orlando; Piero Carninci; Timothy Ravasi

doi:10.1038/srep25039

Characterization of piRNAs across postnatal development in mouse brain

Yanal Ghosheh, Loqmane Seridi, Tae Woo Ryu, Hazuki Takahashi, Valerio Orlando, Piero Carninci, Timothy Ravasi

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31 Scopus citations

Abstract

PIWI-interacting RNAs (piRNAs) are responsible for maintaining the genome stability by silencing retrotransposons in germline tissues– where piRNAs were first discovered and thought to be restricted. Recently, novel functions were reported for piRNAs in germline and somatic cells. Using deep sequencing of small RNAs and CAGE of postnatal development of mouse brain, we identified piRNAs only in adult mouse brain. These piRNAs have similar sequence length as those of MILI-bound piRNAs. In addition, we predicted novel candidate regulators and putative targets of adult brain piRNAs.

Original language	English (US)
Journal	Scientific Reports
Volume	6
Issue number	1
DOIs	https://doi.org/10.1038/srep25039
State	Published - Apr 26 2016

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: Y.G., L.S., T.R.1, V.O. and T.R.2 are supported by King Abdullah University of Science and Technology. Research Grant from the Japanese Ministry of Education, Culture, Sports, Science and Technology (MEXT) to the RIKEN Center for Life Science Technologies. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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10.1038/srep25039

https://repository.kaust.edu.sa/bitstream/10754/607207/1/srep25039.pdf

Cite this

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title = "Characterization of piRNAs across postnatal development in mouse brain",

abstract = "PIWI-interacting RNAs (piRNAs) are responsible for maintaining the genome stability by silencing retrotransposons in germline tissues– where piRNAs were first discovered and thought to be restricted. Recently, novel functions were reported for piRNAs in germline and somatic cells. Using deep sequencing of small RNAs and CAGE of postnatal development of mouse brain, we identified piRNAs only in adult mouse brain. These piRNAs have similar sequence length as those of MILI-bound piRNAs. In addition, we predicted novel candidate regulators and putative targets of adult brain piRNAs.",

author = "Yanal Ghosheh and Loqmane Seridi and Ryu, {Tae Woo} and Hazuki Takahashi and Valerio Orlando and Piero Carninci and Timothy Ravasi",

note = "KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: Y.G., L.S., T.R.1, V.O. and T.R.2 are supported by King Abdullah University of Science and Technology. Research Grant from the Japanese Ministry of Education, Culture, Sports, Science and Technology (MEXT) to the RIKEN Center for Life Science Technologies. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.",

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doi = "10.1038/srep25039",

language = "English (US)",

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AU - Ghosheh, Yanal

AU - Seridi, Loqmane

AU - Ryu, Tae Woo

AU - Takahashi, Hazuki

AU - Orlando, Valerio

AU - Carninci, Piero

AU - Ravasi, Timothy

N1 - KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: Y.G., L.S., T.R.1, V.O. and T.R.2 are supported by King Abdullah University of Science and Technology. Research Grant from the Japanese Ministry of Education, Culture, Sports, Science and Technology (MEXT) to the RIKEN Center for Life Science Technologies. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

PY - 2016/4/26

Y1 - 2016/4/26

N2 - PIWI-interacting RNAs (piRNAs) are responsible for maintaining the genome stability by silencing retrotransposons in germline tissues– where piRNAs were first discovered and thought to be restricted. Recently, novel functions were reported for piRNAs in germline and somatic cells. Using deep sequencing of small RNAs and CAGE of postnatal development of mouse brain, we identified piRNAs only in adult mouse brain. These piRNAs have similar sequence length as those of MILI-bound piRNAs. In addition, we predicted novel candidate regulators and putative targets of adult brain piRNAs.

AB - PIWI-interacting RNAs (piRNAs) are responsible for maintaining the genome stability by silencing retrotransposons in germline tissues– where piRNAs were first discovered and thought to be restricted. Recently, novel functions were reported for piRNAs in germline and somatic cells. Using deep sequencing of small RNAs and CAGE of postnatal development of mouse brain, we identified piRNAs only in adult mouse brain. These piRNAs have similar sequence length as those of MILI-bound piRNAs. In addition, we predicted novel candidate regulators and putative targets of adult brain piRNAs.

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Characterization of piRNAs across postnatal development in mouse brain

Abstract

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