Characterization of piRNAs across postnatal development in mouse brain

Yanal Ghosheh, Loqmane Seridi, Tae Woo Ryu, Hazuki Takahashi, Valerio Orlando, Piero Carninci, Timothy Ravasi

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

PIWI-interacting RNAs (piRNAs) are responsible for maintaining the genome stability by silencing retrotransposons in germline tissues– where piRNAs were first discovered and thought to be restricted. Recently, novel functions were reported for piRNAs in germline and somatic cells. Using deep sequencing of small RNAs and CAGE of postnatal development of mouse brain, we identified piRNAs only in adult mouse brain. These piRNAs have similar sequence length as those of MILI-bound piRNAs. In addition, we predicted novel candidate regulators and putative targets of adult brain piRNAs.
Original languageEnglish (US)
JournalScientific Reports
Volume6
Issue number1
DOIs
StatePublished - Apr 26 2016

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: Y.G., L.S., T.R.1, V.O. and T.R.2 are supported by King Abdullah University of Science and Technology. Research Grant from the Japanese Ministry of Education, Culture, Sports, Science and Technology (MEXT) to the RIKEN Center for Life Science Technologies. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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