Changes in the Arabidopsis RNA-binding proteome reveal novel stress response mechanisms

Claudius Marondedze, Ludivine Thomas, Christoph A Gehring, Kathryn S. Lilley

Research output: Contribution to journalArticlepeer-review

44 Scopus citations


BACKGROUND:RNA-binding proteins (RBPs) are increasingly recognized as regulatory component of post-transcriptional gene expression. RBPs interact with mRNAs via RNA-binding domains and these interactions affect RNA availability for translation, RNA stability and turn-over thus affecting both RNA and protein expression essential for developmental and stimulus specific responses. Here we investigate the effect of severe drought stress on the RNA-binding proteome to gain insights into the mechanisms that govern drought stress responses at the systems level. RESULTS:Label-free mass spectrometry enabled the identification 567 proteins of which 150 significantly responded to the drought-induced treatment. A gene ontology analysis revealed enrichment in the
Original languageEnglish (US)
JournalBMC Plant Biology
Issue number1
StatePublished - Apr 11 2019

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledged KAUST grant number(s): CRG3–62140383
Acknowledgements: The research was funded by the Office of Competitive Research Grant Program, grant number CRG3–62140383, King Abdullah University of Science and Technology (KAUST).


Dive into the research topics of 'Changes in the Arabidopsis RNA-binding proteome reveal novel stress response mechanisms'. Together they form a unique fingerprint.

Cite this