Catecholamines reduce dose-dependent oedema formation and inflammatory reaction in an isolated rat lung model

Christine Dacho*, Andreas Dacho, Antje Geissler, Charlotte Hauser, Kai Nowak, Grietje Beck

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Aim: Since we detected that donor dopamine pre-treatment ameliorates lung function after hypothermia and ischaemia/reperfusion in an isolated rat lung model we studied, whether other catecholamines have beneficial effects on lungs. Materials and Methods: Rats were treated with noradrenaline, adrenaline or dobutamine in different doses. Thereafter lungs were explanted, flushed with Perfadex® solution and stored at 4°C for different time periods. Oedema production was measured and inflammatory mediators were analysed after reperfusion and ventilation. Results: Low-dose noradrenaline or dobutamine did not reduce tissue oedema after eight hours of hypothermia, whereas higher doses significantly reduced oedema formation. Low-dose catecholamines did not prevent the inflammatory response, whereas higher doses of beta-receptor-stimulating catecholamines significantly blunted inflammatory reaction. Conclusion: This study demonstrates that adrenergic-receptor-stimulating catecholamines have a protective dose-dependent effect on lungs after hypothermia and ischaemia/reperfusion. Although noradrenaline and dobutamine have similar dose-dependent organ-protective effects to dopamine, they have more side-effects.

Original languageEnglish (US)
Pages (from-to)49-56
Number of pages8
JournalIn Vivo
Volume27
Issue number1
StatePublished - 2013

Keywords

  • Cold preservation
  • Inflammation
  • Ischaemia/reperfusion
  • Lung transplantation

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology
  • Pharmacology

Fingerprint

Dive into the research topics of 'Catecholamines reduce dose-dependent oedema formation and inflammatory reaction in an isolated rat lung model'. Together they form a unique fingerprint.

Cite this