Cascade Cross-Coupling of Dienes: Photoredox and Nickel Dual Catalysis

Long Huang; Chen Zhu; Liang Yi; Huifeng Yue; Rajesh Kancherla; Magnus Rueping

doi:10.1002/ange.201911109

Cascade Cross-Coupling of Dienes: Photoredox and Nickel Dual Catalysis

Long Huang, Chen Zhu, Liang Yi, Huifeng Yue, Rajesh Kancherla, Magnus Rueping

Research output: Contribution to journal › Article › peer-review

58 Scopus citations

Abstract

Chemical transformations based on cascade reactions have the potential to simplify the preparation of diverse and architecturally complex molecules dramatically. Herein, we disclose an unprecedented and efficient method for the cross-coupling of radical precursors, dienes, and electrophilic coupling partners via a photoredox- and nickel-enabled cascade cross-coupling process. The cascade reaction furnishes a diverse array of saturated carbo- and heterocyclic scaffolds, thus providing access to a quick gain in C−C bond saturation

Original language	English (US)
Pages (from-to)	465-472
Number of pages	8
Journal	Angewandte Chemie
Volume	132
Issue number	1
DOIs	https://doi.org/10.1002/ange.201911109 https://doi.org/10.1002/anie.201911109
State	Published - Nov 28 2019

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: The research leading to these results has received funding from the European Research Council under the European Union's Seventh Framework Programme (FP/2007–2013)/ERC Grant Agreement no. 617044 (SunCatChem).

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title = "Cascade Cross-Coupling of Dienes: Photoredox and Nickel Dual Catalysis",

abstract = "Chemical transformations based on cascade reactions have the potential to simplify the preparation of diverse and architecturally complex molecules dramatically. Herein, we disclose an unprecedented and efficient method for the cross-coupling of radical precursors, dienes, and electrophilic coupling partners via a photoredox- and nickel-enabled cascade cross-coupling process. The cascade reaction furnishes a diverse array of saturated carbo- and heterocyclic scaffolds, thus providing access to a quick gain in C−C bond saturation",

author = "Long Huang and Chen Zhu and Liang Yi and Huifeng Yue and Rajesh Kancherla and Magnus Rueping",

note = "KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: The research leading to these results has received funding from the European Research Council under the European Union's Seventh Framework Programme (FP/2007–2013)/ERC Grant Agreement no. 617044 (SunCatChem).",

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AU - Huang, Long

AU - Zhu, Chen

AU - Yi, Liang

AU - Yue, Huifeng

AU - Kancherla, Rajesh

AU - Rueping, Magnus

N1 - KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: The research leading to these results has received funding from the European Research Council under the European Union's Seventh Framework Programme (FP/2007–2013)/ERC Grant Agreement no. 617044 (SunCatChem).

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Y1 - 2019/11/28

N2 - Chemical transformations based on cascade reactions have the potential to simplify the preparation of diverse and architecturally complex molecules dramatically. Herein, we disclose an unprecedented and efficient method for the cross-coupling of radical precursors, dienes, and electrophilic coupling partners via a photoredox- and nickel-enabled cascade cross-coupling process. The cascade reaction furnishes a diverse array of saturated carbo- and heterocyclic scaffolds, thus providing access to a quick gain in C−C bond saturation

AB - Chemical transformations based on cascade reactions have the potential to simplify the preparation of diverse and architecturally complex molecules dramatically. Herein, we disclose an unprecedented and efficient method for the cross-coupling of radical precursors, dienes, and electrophilic coupling partners via a photoredox- and nickel-enabled cascade cross-coupling process. The cascade reaction furnishes a diverse array of saturated carbo- and heterocyclic scaffolds, thus providing access to a quick gain in C−C bond saturation

UR - http://hdl.handle.net/10754/660485

UR - https://onlinelibrary.wiley.com/doi/abs/10.1002/ange.201911109

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JO - Angewandte Chemie

JF - Angewandte Chemie

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ER -

Cascade Cross-Coupling of Dienes: Photoredox and Nickel Dual Catalysis

Abstract

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