Cardiac cell modelling: Observations from the heart of the cardiac physiome project

Martin Fink, Steven A. Niederer, Elizabeth M. Cherry, Flavio H. Fenton, Jussi T. Koivumäki, Gunnar Seemann, Rüdiger Thul, Henggui Zhang, Frank B. Sachse, Dan Beard, Edmund J. Crampin, Nicolas P. Smith

Research output: Contribution to journalArticlepeer-review

125 Scopus citations

Abstract

In this manuscript we review the state of cardiac cell modelling in the context of international initiatives such as the IUPS Physiome and Virtual Physiological Human Projects, which aim to integrate computational models across scales and physics. In particular we focus on the relationship between experimental data and model parameterisation across a range of model types and cellular physiological systems. Finally, in the context of parameter identification and model reuse within the Cardiac Physiome, we suggest some future priority areas for this field. © 2010 Elsevier Ltd.
Original languageEnglish (US)
Pages (from-to)2-21
Number of pages20
JournalProgress in Biophysics and Molecular Biology
Volume104
Issue number1-3
DOIs
StatePublished - Jan 2011
Externally publishedYes

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledged KAUST grant number(s): KUK-C1-013-04
Acknowledgements: This manuscript is the product of discussions at the Cardiac Physiome Program hosted at, and supported by, the Newton Institute Cambridge United Kingdom. NPS would like to acknowledge support from the United Kingdom Engineering and Physical Sciences Research Council (FP/F059361/1), Biotechnology and Biological Sciences Research Council (BB/F01080X/1) and the European Commission (FP7-ICT-2007-224495: euHeart). FBS acknowledges support by the Nora Eccles Treadwell Foundation. This publication is based on work (by EJC) supported in part by Award No KUK-C1-013-04, made by King Abdullah University of Science and Technology (KAUST). The authors also extend thanks to Liz Gresham for her proofreading of the manuscript.
This publication acknowledges KAUST support, but has no KAUST affiliated authors.

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