Carbon-Germanium Bond Formation via Low-Valent Cobalt-Catalyzed Cross-Electrophile Coupling

Haifeng Chen; Chen Zhu; Huifeng Yue; Magnus Rueping

doi:10.1021/acscatal.3c01244

Carbon-Germanium Bond Formation via Low-Valent Cobalt-Catalyzed Cross-Electrophile Coupling

Haifeng Chen, Chen Zhu, Huifeng Yue, Magnus Rueping^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

An efficient, electrochemically induced cobalt-catalyzed carbon-germanium bond formation provides access to a variety of functionalized germane-containing compounds, including aryl, vinyl, and alkyl germanes. The cobalt-catalyzed germylation is conducted under mild reaction conditions and exhibits a broad scope and functional group tolerance. Mechanistic experimental studies provide insight into the unexpected reaction pathway and the sequential activation of the different electrophiles.

Original language	English (US)
Pages (from-to)	6773-6780
Number of pages	8
Journal	ACS Catalysis
Volume	13
Issue number	10
DOIs	https://doi.org/10.1021/acscatal.3c01244
State	Published - May 19 2023

Bibliographical note

Funding Information:
This work was financially supported by the King Abdullah University of Science and Technology (KAUST), Saudi Arabia, Office of Sponsored Research (URF/1/4405).

Publisher Copyright:
© 2023 American Chemical Society.

Keywords

aryl/alkyl electrophiles
chlorogermanes
cobalt
cross-coupling
electrochemical

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1021/acscatal.3c01244

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title = "Carbon-Germanium Bond Formation via Low-Valent Cobalt-Catalyzed Cross-Electrophile Coupling",

abstract = "An efficient, electrochemically induced cobalt-catalyzed carbon-germanium bond formation provides access to a variety of functionalized germane-containing compounds, including aryl, vinyl, and alkyl germanes. The cobalt-catalyzed germylation is conducted under mild reaction conditions and exhibits a broad scope and functional group tolerance. Mechanistic experimental studies provide insight into the unexpected reaction pathway and the sequential activation of the different electrophiles.",

keywords = "aryl/alkyl electrophiles, chlorogermanes, cobalt, cross-coupling, electrochemical",

author = "Haifeng Chen and Chen Zhu and Huifeng Yue and Magnus Rueping",

note = "Funding Information: This work was financially supported by the King Abdullah University of Science and Technology (KAUST), Saudi Arabia, Office of Sponsored Research (URF/1/4405). Publisher Copyright: {\textcopyright} 2023 American Chemical Society.",

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AU - Chen, Haifeng

AU - Zhu, Chen

AU - Yue, Huifeng

AU - Rueping, Magnus

N1 - Funding Information: This work was financially supported by the King Abdullah University of Science and Technology (KAUST), Saudi Arabia, Office of Sponsored Research (URF/1/4405). Publisher Copyright: © 2023 American Chemical Society.

PY - 2023/5/19

Y1 - 2023/5/19

N2 - An efficient, electrochemically induced cobalt-catalyzed carbon-germanium bond formation provides access to a variety of functionalized germane-containing compounds, including aryl, vinyl, and alkyl germanes. The cobalt-catalyzed germylation is conducted under mild reaction conditions and exhibits a broad scope and functional group tolerance. Mechanistic experimental studies provide insight into the unexpected reaction pathway and the sequential activation of the different electrophiles.

AB - An efficient, electrochemically induced cobalt-catalyzed carbon-germanium bond formation provides access to a variety of functionalized germane-containing compounds, including aryl, vinyl, and alkyl germanes. The cobalt-catalyzed germylation is conducted under mild reaction conditions and exhibits a broad scope and functional group tolerance. Mechanistic experimental studies provide insight into the unexpected reaction pathway and the sequential activation of the different electrophiles.

KW - aryl/alkyl electrophiles

KW - chlorogermanes

KW - cobalt

KW - cross-coupling

KW - electrochemical

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JO - ACS Catalysis

JF - ACS Catalysis

IS - 10

ER -

Carbon-Germanium Bond Formation via Low-Valent Cobalt-Catalyzed Cross-Electrophile Coupling

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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