Cancer-Selective Targeting of the NF-κB Survival Pathway with GADD45β/MKK7 Inhibitors

Laura Tornatore; Annamaria Sandomenico; Domenico Raimondo; Caroline Low; Alberto Rocci; Cathy Tralau-Stewart; Daria Capece; Daniel D’Andrea; Marco Bua; Eileen Boyle; Mark van Duin; Pietro Zoppoli; Albert Jaxa-Chamiec; Anil K. Thotakura; Julian Dyson; Brian A. Walker; Antonio Leonardi; Angela Chambery; Christoph Driessen; Pieter Sonneveld; Gareth Morgan; Antonio Palumbo; Anna Tramontano; Amin Rahemtulla; Menotti Ruvo; Guido Franzoso

doi:10.1016/j.ccell.2014.11.021

Cancer-Selective Targeting of the NF-κB Survival Pathway with GADD45β/MKK7 Inhibitors

Laura Tornatore, Annamaria Sandomenico, Domenico Raimondo, Caroline Low, Alberto Rocci, Cathy Tralau-Stewart, Daria Capece, Daniel D’Andrea, Marco Bua, Eileen Boyle, Mark van Duin, Pietro Zoppoli, Albert Jaxa-Chamiec, Anil K. Thotakura, Julian Dyson, Brian A. Walker, Antonio Leonardi, Angela Chambery, Christoph Driessen, Pieter SonneveldGareth Morgan, Antonio Palumbo, Anna Tramontano, Amin Rahemtulla, Menotti Ruvo, Guido Franzoso

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Original language	English (US)
Pages (from-to)	938
Journal	Cancer Cell
Volume	26
Issue number	6
DOIs	https://doi.org/10.1016/j.ccell.2014.11.021
State	Published - Dec 2014
Externally published	Yes

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledged KAUST grant number(s): KUK-I1-012-43
Acknowledgements: We thank G. Inghirami, F. Dazzi, R. Orlowski, I. Kuiatse, L. Bergsagel, H. Auner, K. Parzych, and A. Karadimitris for cell lines; L. De Colibus, A. De Simone, E. Bellone, and M. Gambella for analytical or technical assistance; G. Cruciani for access to FLAP; and P. Omedè for primary PC samples. We also thank A. Iavarone for critical experimental advice and U. Siebenlist, K. Kelly, M. Lenardo, M. Pagano, H. Walczak, G. Acton, L. Busino, A. De Simone, and E. Tate for critical reading of the manuscript. The work was supported in part by Medical Research Council grants G0901436 and MR/L005069/1, NIH grants CA084040 and CA098583, Cancer Research UK grants A8839 and A15115, and an Imperial Innovations grant to G.F.; Project MERIT FIRB No. RBNE08NKH7_003 to M.R.; King Abdullah University of Science and Technology award KUK-I1-012-43 and PRIN 20108XYHJS to A.T.; and a PRIN 2009 grant to A.P.
This publication acknowledges KAUST support, but has no KAUST affiliated authors.

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10.1016/j.ccell.2014.11.021

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Tornatore, L., Sandomenico, A., Raimondo, D., Low, C., Rocci, A., Tralau-Stewart, C., Capece, D., D’Andrea, D., Bua, M., Boyle, E., van Duin, M., Zoppoli, P., Jaxa-Chamiec, A., Thotakura, AK., Dyson, J., Walker, BA., Leonardi, A., Chambery, A., Driessen, C., ... Franzoso, G. (2014). Cancer-Selective Targeting of the NF-κB Survival Pathway with GADD45β/MKK7 Inhibitors. Cancer Cell, 26(6), 938. https://doi.org/10.1016/j.ccell.2014.11.021

@article{e42819bb35594c84a25ee8001a6aea09,

title = "Cancer-Selective Targeting of the NF-κB Survival Pathway with GADD45β/MKK7 Inhibitors",

author = "Laura Tornatore and Annamaria Sandomenico and Domenico Raimondo and Caroline Low and Alberto Rocci and Cathy Tralau-Stewart and Daria Capece and Daniel D{\textquoteright}Andrea and Marco Bua and Eileen Boyle and Mark van Duin and Pietro Zoppoli and Albert Jaxa-Chamiec and Anil K. Thotakura and Julian Dyson and Brian A. Walker and Antonio Leonardi and Angela Chambery and Christoph Driessen and Pieter Sonneveld and Gareth Morgan and Antonio Palumbo and Anna Tramontano and Amin Rahemtulla and Menotti Ruvo and Guido Franzoso",

note = "KAUST Repository Item: Exported on 2020-10-01 Acknowledged KAUST grant number(s): KUK-I1-012-43 Acknowledgements: We thank G. Inghirami, F. Dazzi, R. Orlowski, I. Kuiatse, L. Bergsagel, H. Auner, K. Parzych, and A. Karadimitris for cell lines; L. De Colibus, A. De Simone, E. Bellone, and M. Gambella for analytical or technical assistance; G. Cruciani for access to FLAP; and P. Omed{\`e} for primary PC samples. We also thank A. Iavarone for critical experimental advice and U. Siebenlist, K. Kelly, M. Lenardo, M. Pagano, H. Walczak, G. Acton, L. Busino, A. De Simone, and E. Tate for critical reading of the manuscript. The work was supported in part by Medical Research Council grants G0901436 and MR/L005069/1, NIH grants CA084040 and CA098583, Cancer Research UK grants A8839 and A15115, and an Imperial Innovations grant to G.F.; Project MERIT FIRB No. RBNE08NKH7_003 to M.R.; King Abdullah University of Science and Technology award KUK-I1-012-43 and PRIN 20108XYHJS to A.T.; and a PRIN 2009 grant to A.P. This publication acknowledges KAUST support, but has no KAUST affiliated authors.",

year = "2014",

month = dec,

doi = "10.1016/j.ccell.2014.11.021",

language = "English (US)",

volume = "26",

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Tornatore, L, Sandomenico, A, Raimondo, D, Low, C, Rocci, A, Tralau-Stewart, C, Capece, D, D’Andrea, D, Bua, M, Boyle, E, van Duin, M, Zoppoli, P, Jaxa-Chamiec, A, Thotakura, AK, Dyson, J, Walker, BA, Leonardi, A, Chambery, A, Driessen, C, Sonneveld, P, Morgan, G, Palumbo, A, Tramontano, A, Rahemtulla, A, Ruvo, M & Franzoso, G 2014, 'Cancer-Selective Targeting of the NF-κB Survival Pathway with GADD45β/MKK7 Inhibitors', Cancer Cell, vol. 26, no. 6, pp. 938. https://doi.org/10.1016/j.ccell.2014.11.021

TY - JOUR

T1 - Cancer-Selective Targeting of the NF-κB Survival Pathway with GADD45β/MKK7 Inhibitors

AU - Tornatore, Laura

AU - Sandomenico, Annamaria

AU - Raimondo, Domenico

AU - Low, Caroline

AU - Rocci, Alberto

AU - Tralau-Stewart, Cathy

AU - Capece, Daria

AU - D’Andrea, Daniel

AU - Bua, Marco

AU - Boyle, Eileen

AU - van Duin, Mark

AU - Zoppoli, Pietro

AU - Jaxa-Chamiec, Albert

AU - Thotakura, Anil K.

AU - Dyson, Julian

AU - Walker, Brian A.

AU - Leonardi, Antonio

AU - Chambery, Angela

AU - Driessen, Christoph

AU - Sonneveld, Pieter

AU - Morgan, Gareth

AU - Palumbo, Antonio

AU - Tramontano, Anna

AU - Rahemtulla, Amin

AU - Ruvo, Menotti

AU - Franzoso, Guido

N1 - KAUST Repository Item: Exported on 2020-10-01 Acknowledged KAUST grant number(s): KUK-I1-012-43 Acknowledgements: We thank G. Inghirami, F. Dazzi, R. Orlowski, I. Kuiatse, L. Bergsagel, H. Auner, K. Parzych, and A. Karadimitris for cell lines; L. De Colibus, A. De Simone, E. Bellone, and M. Gambella for analytical or technical assistance; G. Cruciani for access to FLAP; and P. Omedè for primary PC samples. We also thank A. Iavarone for critical experimental advice and U. Siebenlist, K. Kelly, M. Lenardo, M. Pagano, H. Walczak, G. Acton, L. Busino, A. De Simone, and E. Tate for critical reading of the manuscript. The work was supported in part by Medical Research Council grants G0901436 and MR/L005069/1, NIH grants CA084040 and CA098583, Cancer Research UK grants A8839 and A15115, and an Imperial Innovations grant to G.F.; Project MERIT FIRB No. RBNE08NKH7_003 to M.R.; King Abdullah University of Science and Technology award KUK-I1-012-43 and PRIN 20108XYHJS to A.T.; and a PRIN 2009 grant to A.P. This publication acknowledges KAUST support, but has no KAUST affiliated authors.

PY - 2014/12

Y1 - 2014/12

UR - http://hdl.handle.net/10754/597719

UR - https://linkinghub.elsevier.com/retrieve/pii/S1535610814004723

UR - http://www.scopus.com/inward/record.url?scp=84919467733&partnerID=8YFLogxK

U2 - 10.1016/j.ccell.2014.11.021

DO - 10.1016/j.ccell.2014.11.021

M3 - Article

SN - 1535-6108

VL - 26

SP - 938

JO - Cancer Cell

JF - Cancer Cell

IS - 6

ER -

Cancer-Selective Targeting of the NF-κB Survival Pathway with GADD45β/MKK7 Inhibitors

Bibliographical note

UN SDGs

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