Cancer-Selective Targeting of the NF-κB Survival Pathway with GADD45β/MKK7 Inhibitors

Laura Tornatore, Annamaria Sandomenico, Domenico Raimondo, Caroline Low, Alberto Rocci, Cathy Tralau-Stewart, Daria Capece, Daniel D’Andrea, Marco Bua, Eileen Boyle, Mark van Duin, Pietro Zoppoli, Albert Jaxa-Chamiec, Anil K. Thotakura, Julian Dyson, Brian A. Walker, Antonio Leonardi, Angela Chambery, Christoph Driessen, Pieter SonneveldGareth Morgan, Antonio Palumbo, Anna Tramontano, Amin Rahemtulla, Menotti Ruvo, Guido Franzoso

Research output: Contribution to journalArticlepeer-review

10 Scopus citations
Original languageEnglish (US)
Pages (from-to)938
JournalCancer Cell
Issue number6
StatePublished - Dec 2014
Externally publishedYes

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledged KAUST grant number(s): KUK-I1-012-43
Acknowledgements: We thank G. Inghirami, F. Dazzi, R. Orlowski, I. Kuiatse, L. Bergsagel, H. Auner, K. Parzych, and A. Karadimitris for cell lines; L. De Colibus, A. De Simone, E. Bellone, and M. Gambella for analytical or technical assistance; G. Cruciani for access to FLAP; and P. Omedè for primary PC samples. We also thank A. Iavarone for critical experimental advice and U. Siebenlist, K. Kelly, M. Lenardo, M. Pagano, H. Walczak, G. Acton, L. Busino, A. De Simone, and E. Tate for critical reading of the manuscript. The work was supported in part by Medical Research Council grants G0901436 and MR/L005069/1, NIH grants CA084040 and CA098583, Cancer Research UK grants A8839 and A15115, and an Imperial Innovations grant to G.F.; Project MERIT FIRB No. RBNE08NKH7_003 to M.R.; King Abdullah University of Science and Technology award KUK-I1-012-43 and PRIN 20108XYHJS to A.T.; and a PRIN 2009 grant to A.P.
This publication acknowledges KAUST support, but has no KAUST affiliated authors.

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