Caging the Hofmeister Effect by a Biomimetic Supramolecular Receptor.

Weibin Lin; Gengwu Zhang; Xuanfu zhu; Lukman Olawale Alimi; Basem Moosa; Jonathan L. Sessler; Niveen M. Khashab

doi:10.1021/jacs.3c01849

Caging the Hofmeister Effect by a Biomimetic Supramolecular Receptor.

Weibin Lin, Gengwu Zhang, Xuanfu zhu, Lukman Olawale Alimi, Basem Moosa, Jonathan L. Sessler, Niveen M. Khashab

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The effect of anions on the solubility and function of proteins was recognized in 1888 and is now termed the Hofmeister effect. Numerous synthetic receptors are known that overcome the associated anion recognition bias. However, we are unaware of a synthetic host being used to overcome Hofmeister effect perturbations to natural proteins. Here, we report a protonated small molecule cage complex that acts as an exo-receptor and displays non-Hofmeister solubility behavior, with only the chloride complex remaining soluble in aqueous media. This cage allows for the activity of lysozyme to be retained under conditions where anion-induced precipitation would otherwise cause it to be lost. To our knowledge, this is the first time a synthetic anion receptor is used to overcome the Hofmeister effect in a biological system.

Original language	English (US)
Journal	Journal of the American Chemical Society
DOIs	https://doi.org/10.1021/jacs.3c01849
State	Published - Jun 5 2023

Bibliographical note

KAUST Repository Item: Exported on 2023-06-09
Acknowledged KAUST grant number(s): OSR-2019-CRG8-4032
Acknowledgements: This work was supported by the King Abdullah University of Science and Technology (KAUST; grant OSR-2019-CRG8-4032). Additional support was provided by the Robert A. Welch Foundation (F-0018 to J.L.S.).

ASJC Scopus subject areas

Biochemistry
Colloid and Surface Chemistry
General Chemistry
Catalysis

Access to Document

10.1021/jacs.3c01849

Cite this

@article{2c3ff1f81a9c4fb7bd39aed8f3c57746,

title = "Caging the Hofmeister Effect by a Biomimetic Supramolecular Receptor.",

abstract = "The effect of anions on the solubility and function of proteins was recognized in 1888 and is now termed the Hofmeister effect. Numerous synthetic receptors are known that overcome the associated anion recognition bias. However, we are unaware of a synthetic host being used to overcome Hofmeister effect perturbations to natural proteins. Here, we report a protonated small molecule cage complex that acts as an exo-receptor and displays non-Hofmeister solubility behavior, with only the chloride complex remaining soluble in aqueous media. This cage allows for the activity of lysozyme to be retained under conditions where anion-induced precipitation would otherwise cause it to be lost. To our knowledge, this is the first time a synthetic anion receptor is used to overcome the Hofmeister effect in a biological system.",

author = "Weibin Lin and Gengwu Zhang and Xuanfu zhu and Alimi, {Lukman Olawale} and Basem Moosa and Sessler, {Jonathan L.} and Khashab, {Niveen M.}",

note = "KAUST Repository Item: Exported on 2023-06-09 Acknowledged KAUST grant number(s): OSR-2019-CRG8-4032 Acknowledgements: This work was supported by the King Abdullah University of Science and Technology (KAUST; grant OSR-2019-CRG8-4032). Additional support was provided by the Robert A. Welch Foundation (F-0018 to J.L.S.).",

year = "2023",

month = jun,

day = "5",

doi = "10.1021/jacs.3c01849",

language = "English (US)",

journal = "Journal of the American Chemical Society",

issn = "0002-7863",

publisher = "American Chemical Society",

}

TY - JOUR

T1 - Caging the Hofmeister Effect by a Biomimetic Supramolecular Receptor.

AU - Lin, Weibin

AU - Zhang, Gengwu

AU - zhu, Xuanfu

AU - Alimi, Lukman Olawale

AU - Moosa, Basem

AU - Sessler, Jonathan L.

AU - Khashab, Niveen M.

N1 - KAUST Repository Item: Exported on 2023-06-09 Acknowledged KAUST grant number(s): OSR-2019-CRG8-4032 Acknowledgements: This work was supported by the King Abdullah University of Science and Technology (KAUST; grant OSR-2019-CRG8-4032). Additional support was provided by the Robert A. Welch Foundation (F-0018 to J.L.S.).

PY - 2023/6/5

Y1 - 2023/6/5

N2 - The effect of anions on the solubility and function of proteins was recognized in 1888 and is now termed the Hofmeister effect. Numerous synthetic receptors are known that overcome the associated anion recognition bias. However, we are unaware of a synthetic host being used to overcome Hofmeister effect perturbations to natural proteins. Here, we report a protonated small molecule cage complex that acts as an exo-receptor and displays non-Hofmeister solubility behavior, with only the chloride complex remaining soluble in aqueous media. This cage allows for the activity of lysozyme to be retained under conditions where anion-induced precipitation would otherwise cause it to be lost. To our knowledge, this is the first time a synthetic anion receptor is used to overcome the Hofmeister effect in a biological system.

AB - The effect of anions on the solubility and function of proteins was recognized in 1888 and is now termed the Hofmeister effect. Numerous synthetic receptors are known that overcome the associated anion recognition bias. However, we are unaware of a synthetic host being used to overcome Hofmeister effect perturbations to natural proteins. Here, we report a protonated small molecule cage complex that acts as an exo-receptor and displays non-Hofmeister solubility behavior, with only the chloride complex remaining soluble in aqueous media. This cage allows for the activity of lysozyme to be retained under conditions where anion-induced precipitation would otherwise cause it to be lost. To our knowledge, this is the first time a synthetic anion receptor is used to overcome the Hofmeister effect in a biological system.

UR - http://hdl.handle.net/10754/692439

UR - https://pubs.acs.org/doi/10.1021/jacs.3c01849

U2 - 10.1021/jacs.3c01849

DO - 10.1021/jacs.3c01849

M3 - Article

C2 - 37277952

SN - 0002-7863

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

ER -

Caging the Hofmeister Effect by a Biomimetic Supramolecular Receptor.

Abstract

Bibliographical note

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this