C-Alkylation of Secondary Alcohols by Primary Alcohols through Manganese-Catalyzed Double Hydrogen Autotransfer

Osama El-Sepelgy*, Esteban Matador, Aleksandra Brzozowska, Magnus Rueping

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

59 Scopus citations


A new Mn-catalyzed alkylation of secondary alcohols with non-activated alcohols is presented. The use of a stable and well-defined manganese pincer complex, stabilized by a PNN ligand, together with a catalytic amount of base enabled the conversion of renewable alcohol feedstocks to a broad range of higher-value alcohols in good yields with water as the sole byproduct. The strategy eliminates the need for exogenous and detrimental alkyl halides as well as the use of noble metal catalysts, making the C-alkylation through double hydrogen autotransfer a highly sustainable and environmentally benign process. Mechanistic investigations support a hydrogen autotransfer mechanism in which a non-innocent ligand plays a crucial role.

Original languageEnglish (US)
Pages (from-to)3099-3102
Number of pages4
Issue number13
StatePublished - Jul 5 2019

Bibliographical note

Funding Information:
E.M. acknowledges Ministerio of Economía y Competitividad and Universidad de Sevilla for predoctoral fellowships.

Publisher Copyright:
© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim


  • alcohols
  • alkylation
  • base metals
  • hydrogen autotransfer
  • manganese catalysis

ASJC Scopus subject areas

  • Environmental Chemistry
  • Chemical Engineering(all)
  • Materials Science(all)
  • Energy(all)


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