Brain energy and metabolism

Pierre J. Magistretti; Igor Allaman

doi:10.1007/978-1-4939-3474-4_56

Brain energy and metabolism

Pierre J. Magistretti^*, Igor Allaman

^*Corresponding author for this work

Biological, Environmental Sciences and Engineering

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

4 Scopus citations

Abstract

All the processes described in this textbook require energy. Ample clinical evidence indicates that the brain is exquisitely sensitive to perturbations of energy metabolism. This chapter, adapted from Magistretti PJ (2008) Brain energy metabolism. In: Squire LR, Berg D, Bloom FE, du Lac S, Ghosh A, Spitzer NC (eds) Fundamental neuroscience. Academic, San Diego, pp 271-293, covers the topics of energy delivery, production, and utilization by the brain. Careful consideration of the basic mechanisms of brain energy metabolism is an essential prerequisite to a full understanding of the physiology and pathophysiology of brain function. Abnormalities in brain energy metabolism are observed in a variety of pathological conditions such as neurodegenerative diseases, stroke, epilepsy, and migraine. The chapter reviews the features of brain energy metabolism at the global, regional, and cellular levels and extensively describes recent advances in the understanding of neuroglial metabolic cooperation. A particular focus is the cellular and molecular mechanisms that tightly couple neuronal activity to energy consumption. This tight coupling is at the basis of functional brain-imaging techniques, such as positron emission tomography (PET) and functional magnetic resonance imaging.

Original language	English (US)
Title of host publication	Neuroscience in the 21st Century
Subtitle of host publication	From Basic to Clinical, Second Edition
Publisher	Springer New York
Pages	1879-1909
Number of pages	31
ISBN (Electronic)	9781493934744
ISBN (Print)	9781493934737
DOIs	https://doi.org/10.1007/978-1-4939-3474-4_56
State	Published - Jan 1 2016

Bibliographical note

Publisher Copyright:
© Springer Science+Business Media, LLC 2013 and Springer Science+Business Media New York 2016.

Keywords

Astrocyte-neuron metabolic unit
Blood flow
Brain
Brain energy metabolism
Cell-specific glucose uptake and metabolism
Glial cells
Glucose
Glucose metabolism
Glucose transporters (GLUTs)
Glutamate
Glutamate-stimulated uptake
Glycogen
Glycogen metabolism
Glycolysis
Ketone bodies
Lactate
Lactate and pyruvate serve
NADPH
Neurotransmitters
Pentose phosphate pathway
Tight coupling
Tricarboxylic acid cycle
Vascular endothelial cells

ASJC Scopus subject areas

General Medicine
General Neuroscience
General Agricultural and Biological Sciences

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/978-1-4939-3474-4_56

Cite this

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title = "Brain energy and metabolism",

abstract = "All the processes described in this textbook require energy. Ample clinical evidence indicates that the brain is exquisitely sensitive to perturbations of energy metabolism. This chapter, adapted from Magistretti PJ (2008) Brain energy metabolism. In: Squire LR, Berg D, Bloom FE, du Lac S, Ghosh A, Spitzer NC (eds) Fundamental neuroscience. Academic, San Diego, pp 271-293, covers the topics of energy delivery, production, and utilization by the brain. Careful consideration of the basic mechanisms of brain energy metabolism is an essential prerequisite to a full understanding of the physiology and pathophysiology of brain function. Abnormalities in brain energy metabolism are observed in a variety of pathological conditions such as neurodegenerative diseases, stroke, epilepsy, and migraine. The chapter reviews the features of brain energy metabolism at the global, regional, and cellular levels and extensively describes recent advances in the understanding of neuroglial metabolic cooperation. A particular focus is the cellular and molecular mechanisms that tightly couple neuronal activity to energy consumption. This tight coupling is at the basis of functional brain-imaging techniques, such as positron emission tomography (PET) and functional magnetic resonance imaging.",

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AB - All the processes described in this textbook require energy. Ample clinical evidence indicates that the brain is exquisitely sensitive to perturbations of energy metabolism. This chapter, adapted from Magistretti PJ (2008) Brain energy metabolism. In: Squire LR, Berg D, Bloom FE, du Lac S, Ghosh A, Spitzer NC (eds) Fundamental neuroscience. Academic, San Diego, pp 271-293, covers the topics of energy delivery, production, and utilization by the brain. Careful consideration of the basic mechanisms of brain energy metabolism is an essential prerequisite to a full understanding of the physiology and pathophysiology of brain function. Abnormalities in brain energy metabolism are observed in a variety of pathological conditions such as neurodegenerative diseases, stroke, epilepsy, and migraine. The chapter reviews the features of brain energy metabolism at the global, regional, and cellular levels and extensively describes recent advances in the understanding of neuroglial metabolic cooperation. A particular focus is the cellular and molecular mechanisms that tightly couple neuronal activity to energy consumption. This tight coupling is at the basis of functional brain-imaging techniques, such as positron emission tomography (PET) and functional magnetic resonance imaging.

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Brain energy and metabolism

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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