Brønsted Base Assisted Photoredox Catalysis: Proton Coupled Electron Transfer for Remote C−C Bond Formation via Amidyl Radicals

Jiaqi Jia, Yee Ann Ho, Raoul F. Bülow, Magnus Rueping*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

The synthesis of alkyne- and alkene-decorated lactams has been achieved through a photoredox-initiated radical cascade reaction. The developed Brønsted base assisted, photoredox-catalyzed, intramolecular 5-exo-trig cyclization/intermolecular radical addition/elimination reaction provides facile access to functionalized γ-lactams, with good functional group tolerance and high yields.

Original languageEnglish (US)
Pages (from-to)14054-14058
Number of pages5
JournalChemistry - A European Journal
Volume24
Issue number53
DOIs
StatePublished - Sep 20 2018

Bibliographical note

Publisher Copyright:
© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

Keywords

  • Brønsted base
  • lactam derivatives
  • photoredox catalysis
  • proton-coupled electron transfer (PCET)
  • radical reactions
  • sulfonyl radical

ASJC Scopus subject areas

  • General Chemistry
  • Catalysis
  • Organic Chemistry

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