Brønsted Base Assisted Photoredox Catalysis: Proton Coupled Electron Transfer for Remote C−C Bond Formation via Amidyl Radicals

Jiaqi Jia, Yee Ann Ho, Raoul F. Bülow, Magnus Rueping

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

The synthesis of alkyne- and alkene-decorated lactams has been achieved through a photoredox-initiated radical cascade reaction. The developed Brønsted base assisted, photoredox-catalyzed, intramolecular 5-exo-trig cyclization/intermolecular radical addition/elimination reaction provides facile access to functionalized γ-lactams, with good functional group tolerance and high yields.
Original languageEnglish (US)
Pages (from-to)14054-14058
Number of pages5
JournalChemistry - A European Journal
Volume24
Issue number53
DOIs
StatePublished - Aug 27 2018

Bibliographical note

KAUST Repository Item: Exported on 2020-04-23
Acknowledgements: Y.A.H. would like to thank Deutscher Akademischer Austauschdienst (DAAD) for a doctoral scholarship. The research leading to these results has received funding from the European Research Council under the European Union's Seventh Framework Programme (FP/2007–2013)/ERC Grant Agreement no. 617044 (SunCatChem).

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