Brønsted acid catalyzed enantioselective addition of hydrazones to 3-indolylmethanols

Steffen Mader, Modhu Sudan Maji, Iuliana Atodiresei, Magnus Rueping

Research output: Contribution to journalArticlepeer-review

Abstract

The organocatalytic asymmetric addition of hydrazones to indole derivatives in the presence of chiral Brønsted acids is reported. A large variety of substrates are tolerated and the products are obtained in good yields and with excellent enantioselectivities. This metal-free reaction provides a convenient route to enantiopure β-substituted tryptophan derivatives in a concise fashion.
Original languageEnglish (US)
JournalOrganic Chemistry Frontiers
DOIs
StatePublished - Jul 15 2022

ASJC Scopus subject areas

  • Organic Chemistry

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