Block Copolymer-Based Magnetic Mixed Matrix Membranes—Effect of Magnetic Field on Protein Permeation and Membrane Fouling

Lakshmeesha Upadhyaya, Mona Semsarilar, Damien Quemener, Rodrigo Fernández-Pacheco, Gema Martinez, Isabel M. Coelhoso, Suzana Pereira Nunes, João G. Crespo, Reyes Mallada, Carla A. M. Portugal

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

In this study, we report the impact of the magnetic field on protein permeability through magnetic-responsive, block copolymer, nanocomposite membranes with hydrophilic and hydrophobic characters. The hydrophilic nanocomposite membranes were composed of spherical polymeric nanoparticles (NPs) synthesized through polymerization-induced self-assembly (PISA) with iron oxide NPs coated with quaternized poly(2-dimethylamino)ethyl methacrylate. The hydrophobic nanocomposite membranes were prepared via nonsolvent-induced phase separation (NIPS) containing poly (methacrylic acid) and meso-2,3-dimercaptosuccinic acid-coated superparamagnetic nanoparticles (SPNPs). The permeation experiments were carried out using bovine serum albumin (BSA) as the model solute, in the absence of the magnetic field and under permanent and cyclic magnetic field conditions OFF/ON (strategy 1) and ON/OFF (strategy 2). It was observed that the magnetic field led to a lower reduction in the permeate fluxes of magnetic-responsive membranes during BSA permeation, regardless of the magnetic field strategy used, than that obtained in the absence of the magnetic field. Nevertheless, a comparative analysis of the effect caused by the two cyclic magnetic field strategies showed that strategy 2 allowed for a lower reduction of the original permeate fluxes during BSA permeation and higher protein sieving coefficients. Overall, these novel magneto-responsive block copolymer nanocomposite membranes proved to be competent in mitigating biofouling phenomena in bioseparation processes.
Original languageEnglish (US)
Pages (from-to)105
JournalMembranes
Volume11
Issue number2
DOIs
StatePublished - Feb 2 2021

Bibliographical note

KAUST Repository Item: Exported on 2021-02-11
Acknowledgements: Lakshmeesha Upadhyaya acknowledges the doctorate completed at the Institut Européen des Membranes and carried out in three universities: Université de Montpellier (France), Universidad de Zaragoza (Spain) and Universidade Nova de Lisboa (Portugal) and supported by European Commission—Education, Audiovisual and Culture Executive Agency (EACEA), under the program: Erasmus Mundus Doctorate in Membrane Engineering—EUDIME (FPA N◦ 2011–0014, Edition III, http:/eudime.unical.it). CIBER-BBN (initiative funded by the VI National R&D&i Plan 2008– 2011), Iniciativa Ingenio 2010, Consolider Program, is gratefully acknowledged. The synthesis of the inorganic nanomaterials has been performed by the Synthesis of Nanoparticles Unit of the ICTS “NANBIOSIS” at the Institute of Nanoscience of Aragon (INA)-Universidad de Zaragoza.

Fingerprint

Dive into the research topics of 'Block Copolymer-Based Magnetic Mixed Matrix Membranes—Effect of Magnetic Field on Protein Permeation and Membrane Fouling'. Together they form a unique fingerprint.

Cite this