Biomimics of Metalloenzymes via Imprinting

Gyorgy Szekely*, Christos Didaskalou

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

6 Scopus citations


Metals have a vital role in catalysis, and their ability specifically to coordinate molecular structures has been exploited by nature with the development of metalloenzymes. Inspired by nature, chemists have been extensively using metals to catalyze a broad range of difficult transformations. The imprinting approach for the preparation of biomimics of metalloenzymes gives highly selective and robust catalysts applicable to molecular recognition processes with challenging conditions (e.g., high temperatures and pressures, extreme pHs, and organic solvents). Imprinted metal-containing catalysts can also be designed for reactions that are not catalyzed by natural enzymes, such as degradation of soil and water contaminants or hydrogen production. Imprinted biomimics of metalloenzymes are categorized and discussed based on templates, metal ions, polymerization techniques, imprinting approaches, and catalytic reactions. Initial studies focusing on proof-of-concepts in mimicking natural enzymes as well as state-of-the-art catalytic devices including nanogels, nanoreactors, and biosensors are discussed. Rational design methodologies and statistical designs of experiments are expected to assist the screening of matrices for their catalytic performance and consequently accelerate further development of the field.

Original languageEnglish (US)
Title of host publicationMolecularly Imprinted Catalysts
Subtitle of host publicationPrinciples, Syntheses, and Applications
PublisherElsevier Inc.
Number of pages38
ISBN (Print)9780128013014
StatePublished - Jan 1 2016


  • Asymmetric synthesis
  • Catalyst immobilization
  • Coupling reactions
  • Nanoreactors
  • Transition metals

ASJC Scopus subject areas

  • General Engineering
  • General Chemical Engineering


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