Biofunctionalized Two-Dimensional Ti3C2 MXenes for Ultrasensitive Detection of Cancer Biomarker

Saurabh Kumar, Yongjiu Lei, Niman H. Alshareef, M.A. Quevedo-Lopez, Khaled N. Salama

Research output: Contribution to journalArticlepeer-review

307 Scopus citations


In this work, ultrathin Ti3C2-MXene nanosheets were synthesized by minimally intensive layer delamination methods, and uniformly functionalized with aminosilane (f-Ti3C2-MXene) to provide a covalent binding for the immobilized bio-receptor (anti-CEA) for label free, ultrasensitive detection of cancer biomarker (carcinoembryonic antigen, CEA). The effect of different redox probes on the electrochemical behavior of f-Ti3C2-MXene was investigated and found that hexaammineruthenium ([Ru(NH3)6]3+) is the preferable redox probe for biosensing. The fabricated biofunctionalized Ti3C2-MXene exhibits a linear detection range of 0.0001–2000 ngmL−1 with sensitivity of 37.9 µAng−1mLcm−2 per decade. The wider linear detection range of our f-Ti3C2-MXene is not only higher than previously reported pristine 2D nanomaterials, but is even comparable to other hybrid 2D nanomaterials. We believe that this work opens a new window for development of MXene-based highly sensitive DNA, aptamer, enzyme, antibody, and cell based biosensors, and could be further used in drug delivery application.
Original languageEnglish (US)
Pages (from-to)243-249
Number of pages7
JournalBiosensors and Bioelectronics
StatePublished - Aug 31 2018

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: We thank Prof. Sahika Inal for providing the serum sample. Research reported in this publication was supported by funding from King Abdullah University of Science and Technology (KAUST).


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