Biodegradable polymer based particulate carrier(s) for the delivery of proteins and peptides

Neeraj Mishra, Amit K. Goyal, Kapil Khatri, Bhuvaneshwar Vaidya, Rishi Paliwal, Shivani Rai, Abhinav Mehta, Shailja Tiwari, Shiva Vyas, Suresh P. Vyas

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

Construction of safe and effective delivery systems for proteins and peptides is demand of current clinical practices. Biodegradable polymers based particulates carriers fulfill much of the requirement in this applicable field. Number of marketed products related to biodegradable polymers encapsulating proteins is increasing. However, it has not achieved its proper place since problems related to the protein processing and stabilization limits the scientific community. In this present review we have summarized various aspects related to the formulation and processing of biodegradable polymerized microparticles/ nanoparticles for delivery of therapeutic proteins and peptides. A brief introduction of biodegradable polymers has been incorporated for reader's benefit. In addition, biodegradable polymers based carriers designed for vaccine delivery has been incorporated in detail. Functionalized biodegradable carrier(s) for site specific delivery of proteineous matter has also been discussed. © 2008 Bentham Science Publishers Ltd.
Original languageEnglish (US)
Pages (from-to)240-251
Number of pages12
JournalAnti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry
Volume7
Issue number4
DOIs
StatePublished - Dec 1 2008
Externally publishedYes

Bibliographical note

Generated from Scopus record by KAUST IRTS on 2023-10-12

ASJC Scopus subject areas

  • Immunology
  • Pharmacology
  • Immunology and Allergy

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