Biodegradable Oxamide-Phenylene-Based Mesoporous Organosilica Nanoparticles with Unprecedented Drug Payloads for Delivery in Cells

Jonas Croissant, Yevhen Fatieiev, Khachatur Julfakyan, Jie Lu, Abdelhamid Emwas, Dalaver H. Anjum, Haneen Omar, Fuyuhiko Tamanoi, Jeffrey Zink, Niveen M. Khashab

Research output: Contribution to journalArticlepeer-review

78 Scopus citations

Abstract

We describe biodegradable mesoporous hybrid NPs in the presence of proteins, and its application for drug delivery. We synthesized oxamide-phenylene-based mesoporous organosilica nanoparticles (MON) in the absence of silica source which had a remarkably high organic content with a high surface area. Oxamide functions provided biodegradability in the presence of trypsin model proteins. MON displayed exceptionally high payloads of hydrophilic and hydrophobic drugs (up to 84 wt%), and a unique zero premature leakage without the pore capping, unlike mesoporous silica. MON were biocompatible and internalized into cancer cells for drug delivery.
Original languageEnglish (US)
Pages (from-to)14806-14811
Number of pages6
JournalChemistry - A European Journal
Volume22
Issue number42
DOIs
StatePublished - Jun 30 2016

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: The authors gratefully acknowledge King Abdullah University of
Science and Technology and the University of California, Los
Angeles for the support of this work.

ASJC Scopus subject areas

  • General Chemistry

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