Biodegradable Oxamide-Phenylene-Based Mesoporous Organosilica Nanoparticles with Unprecedented Drug Payloads for Delivery in Cells

Jonas Croissant; Yevhen Fatieiev; Khachatur Julfakyan; Jie Lu; Abdelhamid Emwas; Dalaver H. Anjum; Haneen Omar; Fuyuhiko Tamanoi; Jeffrey Zink; Niveen M. Khashab

doi:10.1002/chem.201601714

Biodegradable Oxamide-Phenylene-Based Mesoporous Organosilica Nanoparticles with Unprecedented Drug Payloads for Delivery in Cells

Jonas Croissant, Yevhen Fatieiev, Khachatur Julfakyan, Jie Lu, Abdelhamid Emwas, Dalaver H. Anjum, Haneen Omar, Fuyuhiko Tamanoi, Jeffrey Zink, Niveen M. Khashab

Research output: Contribution to journal › Article › peer-review

83 Scopus citations

Abstract

We describe biodegradable mesoporous hybrid NPs in the presence of proteins, and its application for drug delivery. We synthesized oxamide-phenylene-based mesoporous organosilica nanoparticles (MON) in the absence of silica source which had a remarkably high organic content with a high surface area. Oxamide functions provided biodegradability in the presence of trypsin model proteins. MON displayed exceptionally high payloads of hydrophilic and hydrophobic drugs (up to 84 wt%), and a unique zero premature leakage without the pore capping, unlike mesoporous silica. MON were biocompatible and internalized into cancer cells for drug delivery.

Original language	English (US)
Pages (from-to)	14806-14811
Number of pages	6
Journal	Chemistry - A European Journal
Volume	22
Issue number	42
DOIs	https://doi.org/10.1002/chem.201601714
State	Published - Jun 30 2016

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: The authors gratefully acknowledge King Abdullah University of
Science and Technology and the University of California, Los
Angeles for the support of this work.

ASJC Scopus subject areas

General Chemistry

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10.1002/chem.201601714

https://repository.kaust.edu.sa/bitstream/10754/612998/1/Croissant_et_al-2016-Chemistry_-_A_European_Journal.pdf

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title = "Biodegradable Oxamide-Phenylene-Based Mesoporous Organosilica Nanoparticles with Unprecedented Drug Payloads for Delivery in Cells",

abstract = "We describe biodegradable mesoporous hybrid NPs in the presence of proteins, and its application for drug delivery. We synthesized oxamide-phenylene-based mesoporous organosilica nanoparticles (MON) in the absence of silica source which had a remarkably high organic content with a high surface area. Oxamide functions provided biodegradability in the presence of trypsin model proteins. MON displayed exceptionally high payloads of hydrophilic and hydrophobic drugs (up to 84 wt%), and a unique zero premature leakage without the pore capping, unlike mesoporous silica. MON were biocompatible and internalized into cancer cells for drug delivery.",

author = "Jonas Croissant and Yevhen Fatieiev and Khachatur Julfakyan and Jie Lu and Abdelhamid Emwas and Anjum, {Dalaver H.} and Haneen Omar and Fuyuhiko Tamanoi and Jeffrey Zink and Khashab, {Niveen M.}",

note = "KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: The authors gratefully acknowledge King Abdullah University of Science and Technology and the University of California, Los Angeles for the support of this work.",

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AU - Croissant, Jonas

AU - Fatieiev, Yevhen

AU - Julfakyan, Khachatur

AU - Lu, Jie

AU - Emwas, Abdelhamid

AU - Anjum, Dalaver H.

AU - Omar, Haneen

AU - Tamanoi, Fuyuhiko

AU - Zink, Jeffrey

AU - Khashab, Niveen M.

N1 - KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: The authors gratefully acknowledge King Abdullah University of Science and Technology and the University of California, Los Angeles for the support of this work.

PY - 2016/6/30

Y1 - 2016/6/30

N2 - We describe biodegradable mesoporous hybrid NPs in the presence of proteins, and its application for drug delivery. We synthesized oxamide-phenylene-based mesoporous organosilica nanoparticles (MON) in the absence of silica source which had a remarkably high organic content with a high surface area. Oxamide functions provided biodegradability in the presence of trypsin model proteins. MON displayed exceptionally high payloads of hydrophilic and hydrophobic drugs (up to 84 wt%), and a unique zero premature leakage without the pore capping, unlike mesoporous silica. MON were biocompatible and internalized into cancer cells for drug delivery.

AB - We describe biodegradable mesoporous hybrid NPs in the presence of proteins, and its application for drug delivery. We synthesized oxamide-phenylene-based mesoporous organosilica nanoparticles (MON) in the absence of silica source which had a remarkably high organic content with a high surface area. Oxamide functions provided biodegradability in the presence of trypsin model proteins. MON displayed exceptionally high payloads of hydrophilic and hydrophobic drugs (up to 84 wt%), and a unique zero premature leakage without the pore capping, unlike mesoporous silica. MON were biocompatible and internalized into cancer cells for drug delivery.

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JO - Chemistry - A European Journal

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ER -

Biodegradable Oxamide-Phenylene-Based Mesoporous Organosilica Nanoparticles with Unprecedented Drug Payloads for Delivery in Cells

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

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