TY - JOUR
T1 - Biodegradable Magnetic Silica@Iron Oxide Nanovectors with Ultra-Large Mesopores for High Protein Loading, Magnetothermal Release, and Delivery
AU - Omar, Haneen
AU - Croissant, Jonas G.
AU - Alamoudi, Kholod
AU - Alsaiari, Shahad K.
AU - Alradwan, Ibrahim
AU - Majrashi, Majed A.
AU - Anjum, Dalaver H.
AU - Martins, Patricia
AU - Moosa, Basem
AU - Almalik, Abdulaziz
AU - Khashab, Niveen M.
N1 - KAUST Repository Item: Exported on 2020-10-01
PY - 2016/11/29
Y1 - 2016/11/29
N2 - The delivery of large cargos of diameter above 15 nm for biomedical applications has proved challenging since it requires biocompatible, stably-loaded, and biodegradable nanomaterials. In this study, we describe the design of biodegradable silica-iron oxide hybrid nanovectors with large mesopores for large protein delivery in cancer cells. The mesopores of the nanomaterials spanned from 20 to 60 nm in diameter and post-functionalization allowed the electrostatic immobilization of large proteins (e.g. mTFP-Ferritin, ~ 534 kDa). Half of the content of the nanovectors was based with iron oxide nanophases which allowed the rapid biodegradation of the carrier in fetal bovine serum and a magnetic responsiveness. The nanovectors released large protein cargos in aqueous solution under acidic pH or magnetic stimuli. The delivery of large proteins was then autonomously achieved in cancer cells via the silica-iron oxide nanovectors, which is thus a promising for biomedical applications.
AB - The delivery of large cargos of diameter above 15 nm for biomedical applications has proved challenging since it requires biocompatible, stably-loaded, and biodegradable nanomaterials. In this study, we describe the design of biodegradable silica-iron oxide hybrid nanovectors with large mesopores for large protein delivery in cancer cells. The mesopores of the nanomaterials spanned from 20 to 60 nm in diameter and post-functionalization allowed the electrostatic immobilization of large proteins (e.g. mTFP-Ferritin, ~ 534 kDa). Half of the content of the nanovectors was based with iron oxide nanophases which allowed the rapid biodegradation of the carrier in fetal bovine serum and a magnetic responsiveness. The nanovectors released large protein cargos in aqueous solution under acidic pH or magnetic stimuli. The delivery of large proteins was then autonomously achieved in cancer cells via the silica-iron oxide nanovectors, which is thus a promising for biomedical applications.
UR - http://hdl.handle.net/10754/621898
UR - http://www.sciencedirect.com/science/article/pii/S0168365916312251
UR - http://www.scopus.com/inward/record.url?scp=85009250606&partnerID=8YFLogxK
U2 - 10.1016/j.jconrel.2016.11.032
DO - 10.1016/j.jconrel.2016.11.032
M3 - Article
C2 - 27913308
SN - 0168-3659
VL - 259
SP - 187
EP - 194
JO - Journal of Controlled Release
JF - Journal of Controlled Release
ER -
