AVP1: One Protein, Many Roles

Rhiannon K. Schilling, Mark A. Tester, Petra Marschner, Darren C. Plett, Stuart J. Roy

Research output: Contribution to journalArticlepeer-review

64 Scopus citations


Constitutive expression of the Arabidopsis vacuolar proton-pumping pyrophosphatase (H+-PPase) gene (AVP1) increases plant growth under various abiotic stress conditions and, importantly, under nonstressed conditions. Many interpretations have been proposed to explain these phenotypes, including greater vacuolar ion sequestration, increased auxin transport, enhanced heterotrophic growth, and increased transport of sucrose from source to sink tissues. In this review, we evaluate all the roles proposed for AVP1, using findings published to date from mutant plants lacking functional AVP1 and transgenic plants expressing AVP1. It is clear that AVP1 is one protein with many roles, and that one or more of these roles act to enhance plant growth. The complexity suggests that a systems biology approach to evaluate biological networks is required to investigate these intertwined roles.
Original languageEnglish (US)
Pages (from-to)154-162
Number of pages9
JournalTrends in Plant Science
Issue number2
StatePublished - Dec 16 2016

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: We acknowledge funding from the Grains Research and Development Corporation (GRDC; GRS10044, UA00145, UA00159, ACP00009), International Wheat Yield Partnership (IWYP; IWYP39) and King Abdullah University of Science and Technology (KAUST).


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