AtPIN4 mediates sink-driven auxin gradients and root patterning in Arabidopsis

Jiří Friml; Eva Benková; Ikram Blilou; Justyna Wisniewska; Thorsten Hamann; Karin Ljung; Scott Woody; Goran Sandberg; Ben Scheres; Gerd Jürgens; Klaus Palme

doi:10.1016/S0092-8674(02)00656-6

AtPIN4 mediates sink-driven auxin gradients and root patterning in Arabidopsis

Jiří Friml, Eva Benková, Ikram Blilou, Justyna Wisniewska, Thorsten Hamann, Karin Ljung, Scott Woody, Goran Sandberg, Ben Scheres, Gerd Jürgens, Klaus Palme^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

703 Scopus citations

Abstract

In contrast to animals, little is known about pattern formation in plants. Physiological and genetic data suggest the involvement of the phytohormone auxin in this process. Here, we characterize a novel member of the PIN family of putative auxin efflux carriers, Arabidopsis PIN4, that is localized in developing and mature root meristems. Atpin4 mutants are defective in establishment and maintenance of endogenous auxin gradients, fail to canalize externally applied auxin, and display various patterning defects in both embryonic and seedling roots. We propose a role for AtPIN4 in generating a sink for auxin below the quiescent center of the root meristem that is essential for auxin distribution and patterning.

Original language	English (US)
Pages (from-to)	661-673
Number of pages	13
Journal	Cell
Volume	108
Issue number	5
DOIs	https://doi.org/10.1016/S0092-8674(02)00656-6
State	Published - Mar 8 2002
Externally published	Yes

Bibliographical note

Funding Information:
We thank Petra Tänzler, Michaela Lehnen, and Thomas Steinmann for technical help. We acknowledge the Arabidopsis Biological Resource Center (Columbus, OH) and Thomas Altman for providing material. We also gratefully acknowledge the ADIS service group for DNA sequencing and ZIGIA (Center for Functional Genomics in Arabidopsis) for the En lines. We are grateful to our colleagues, particularly Leo Gälweiler, Niko Geldner, Matthias Godde, and Kathrin Schrick for critical reading of the manuscript. This work was supported by a fellowship of the Deutscher Akademischer Austauschdienset (J.F.), the Deutsche Forschungsgemeinschaft (Schwerpunktprogramm Phytohormone), the European Communities Biotechnology Programs, the Fonds der Chemischen Industrie, and the INCO-Copernicus Program.

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

Access to Document

10.1016/S0092-8674(02)00656-6

Cite this

@article{82f4ffe3fc734faba327ddc18c6eba11,

title = "AtPIN4 mediates sink-driven auxin gradients and root patterning in Arabidopsis",

abstract = "In contrast to animals, little is known about pattern formation in plants. Physiological and genetic data suggest the involvement of the phytohormone auxin in this process. Here, we characterize a novel member of the PIN family of putative auxin efflux carriers, Arabidopsis PIN4, that is localized in developing and mature root meristems. Atpin4 mutants are defective in establishment and maintenance of endogenous auxin gradients, fail to canalize externally applied auxin, and display various patterning defects in both embryonic and seedling roots. We propose a role for AtPIN4 in generating a sink for auxin below the quiescent center of the root meristem that is essential for auxin distribution and patterning.",

author = "Ji{\v r}{\'i} Friml and Eva Benkov{\'a} and Ikram Blilou and Justyna Wisniewska and Thorsten Hamann and Karin Ljung and Scott Woody and Goran Sandberg and Ben Scheres and Gerd J{\"u}rgens and Klaus Palme",

note = "Funding Information: We thank Petra T{\"a}nzler, Michaela Lehnen, and Thomas Steinmann for technical help. We acknowledge the Arabidopsis Biological Resource Center (Columbus, OH) and Thomas Altman for providing material. We also gratefully acknowledge the ADIS service group for DNA sequencing and ZIGIA (Center for Functional Genomics in Arabidopsis) for the En lines. We are grateful to our colleagues, particularly Leo G{\"a}lweiler, Niko Geldner, Matthias Godde, and Kathrin Schrick for critical reading of the manuscript. This work was supported by a fellowship of the Deutscher Akademischer Austauschdienset (J.F.), the Deutsche Forschungsgemeinschaft (Schwerpunktprogramm Phytohormone), the European Communities Biotechnology Programs, the Fonds der Chemischen Industrie, and the INCO-Copernicus Program. ",

year = "2002",

month = mar,

day = "8",

doi = "10.1016/S0092-8674(02)00656-6",

language = "English (US)",

volume = "108",

pages = "661--673",

journal = "Cell",

issn = "0092-8674",

publisher = "Elsevier B.V.",

number = "5",

}

TY - JOUR

T1 - AtPIN4 mediates sink-driven auxin gradients and root patterning in Arabidopsis

AU - Friml, Jiří

AU - Benková, Eva

AU - Blilou, Ikram

AU - Wisniewska, Justyna

AU - Hamann, Thorsten

AU - Ljung, Karin

AU - Woody, Scott

AU - Sandberg, Goran

AU - Scheres, Ben

AU - Jürgens, Gerd

AU - Palme, Klaus

N1 - Funding Information: We thank Petra Tänzler, Michaela Lehnen, and Thomas Steinmann for technical help. We acknowledge the Arabidopsis Biological Resource Center (Columbus, OH) and Thomas Altman for providing material. We also gratefully acknowledge the ADIS service group for DNA sequencing and ZIGIA (Center for Functional Genomics in Arabidopsis) for the En lines. We are grateful to our colleagues, particularly Leo Gälweiler, Niko Geldner, Matthias Godde, and Kathrin Schrick for critical reading of the manuscript. This work was supported by a fellowship of the Deutscher Akademischer Austauschdienset (J.F.), the Deutsche Forschungsgemeinschaft (Schwerpunktprogramm Phytohormone), the European Communities Biotechnology Programs, the Fonds der Chemischen Industrie, and the INCO-Copernicus Program.

PY - 2002/3/8

Y1 - 2002/3/8

N2 - In contrast to animals, little is known about pattern formation in plants. Physiological and genetic data suggest the involvement of the phytohormone auxin in this process. Here, we characterize a novel member of the PIN family of putative auxin efflux carriers, Arabidopsis PIN4, that is localized in developing and mature root meristems. Atpin4 mutants are defective in establishment and maintenance of endogenous auxin gradients, fail to canalize externally applied auxin, and display various patterning defects in both embryonic and seedling roots. We propose a role for AtPIN4 in generating a sink for auxin below the quiescent center of the root meristem that is essential for auxin distribution and patterning.

AB - In contrast to animals, little is known about pattern formation in plants. Physiological and genetic data suggest the involvement of the phytohormone auxin in this process. Here, we characterize a novel member of the PIN family of putative auxin efflux carriers, Arabidopsis PIN4, that is localized in developing and mature root meristems. Atpin4 mutants are defective in establishment and maintenance of endogenous auxin gradients, fail to canalize externally applied auxin, and display various patterning defects in both embryonic and seedling roots. We propose a role for AtPIN4 in generating a sink for auxin below the quiescent center of the root meristem that is essential for auxin distribution and patterning.

UR - http://www.scopus.com/inward/record.url?scp=18344379498&partnerID=8YFLogxK

U2 - 10.1016/S0092-8674(02)00656-6

DO - 10.1016/S0092-8674(02)00656-6

M3 - Article

C2 - 11893337

AN - SCOPUS:18344379498

SN - 0092-8674

VL - 108

SP - 661

EP - 673

JO - Cell

JF - Cell

IS - 5

ER -

AtPIN4 mediates sink-driven auxin gradients and root patterning in Arabidopsis

Abstract

Bibliographical note

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this