AtPIN4 mediates sink-driven auxin gradients and root patterning in Arabidopsis

Jiří Friml, Eva Benková, Ikram Blilou, Justyna Wisniewska, Thorsten Hamann, Karin Ljung, Scott Woody, Goran Sandberg, Ben Scheres, Gerd Jürgens, Klaus Palme*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

693 Scopus citations

Abstract

In contrast to animals, little is known about pattern formation in plants. Physiological and genetic data suggest the involvement of the phytohormone auxin in this process. Here, we characterize a novel member of the PIN family of putative auxin efflux carriers, Arabidopsis PIN4, that is localized in developing and mature root meristems. Atpin4 mutants are defective in establishment and maintenance of endogenous auxin gradients, fail to canalize externally applied auxin, and display various patterning defects in both embryonic and seedling roots. We propose a role for AtPIN4 in generating a sink for auxin below the quiescent center of the root meristem that is essential for auxin distribution and patterning.

Original languageEnglish (US)
Pages (from-to)661-673
Number of pages13
JournalCell
Volume108
Issue number5
DOIs
StatePublished - Mar 8 2002
Externally publishedYes

Bibliographical note

Funding Information:
We thank Petra Tänzler, Michaela Lehnen, and Thomas Steinmann for technical help. We acknowledge the Arabidopsis Biological Resource Center (Columbus, OH) and Thomas Altman for providing material. We also gratefully acknowledge the ADIS service group for DNA sequencing and ZIGIA (Center for Functional Genomics in Arabidopsis) for the En lines. We are grateful to our colleagues, particularly Leo Gälweiler, Niko Geldner, Matthias Godde, and Kathrin Schrick for critical reading of the manuscript. This work was supported by a fellowship of the Deutscher Akademischer Austauschdienset (J.F.), the Deutsche Forschungsgemeinschaft (Schwerpunktprogramm Phytohormone), the European Communities Biotechnology Programs, the Fonds der Chemischen Industrie, and the INCO-Copernicus Program.

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology

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