Abstract
An enantioselective synthesis of spirocyclic indoline scaffolds was achieved by applying an asymmetric iridium-catalyzed hydrogenation of 3H-indoles. Low catalyst loadings and mild reaction conditions provide a broad range of differently substituted products with excellent yields and enantioselectivities. The developed methodology allows an efficient synthesis of this important spirocyclic structural motif, which is present in numerous biologically active molecules and privileged structures in medicinal chemistry.
Original language | English (US) |
---|---|
Pages (from-to) | 798-801 |
Number of pages | 4 |
Journal | Chemistry - A European Journal |
Volume | 23 |
Issue number | 4 |
DOIs | |
State | Published - Dec 15 2016 |
Bibliographical note
KAUST Repository Item: Exported on 2020-10-01Acknowledgements: The authors thank Solvias AG and Evonik Industries AG for donation of chiral ligands and metal salts.