TY - JOUR
T1 - Asymmetric Synthesis of Optically Active Spirocyclic Indoline Scaffolds through an Enantioselective Reduction of Indoles
AU - Borrmann, Ruediger
AU - Knop, Nils
AU - Rueping, Magnus
N1 - KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: The authors thank Solvias AG and Evonik Industries AG for donation of chiral ligands and metal salts.
PY - 2016/12/15
Y1 - 2016/12/15
N2 - An enantioselective synthesis of spirocyclic indoline scaffolds was achieved by applying an asymmetric iridium-catalyzed hydrogenation of 3H-indoles. Low catalyst loadings and mild reaction conditions provide a broad range of differently substituted products with excellent yields and enantioselectivities. The developed methodology allows an efficient synthesis of this important spirocyclic structural motif, which is present in numerous biologically active molecules and privileged structures in medicinal chemistry.
AB - An enantioselective synthesis of spirocyclic indoline scaffolds was achieved by applying an asymmetric iridium-catalyzed hydrogenation of 3H-indoles. Low catalyst loadings and mild reaction conditions provide a broad range of differently substituted products with excellent yields and enantioselectivities. The developed methodology allows an efficient synthesis of this important spirocyclic structural motif, which is present in numerous biologically active molecules and privileged structures in medicinal chemistry.
UR - http://hdl.handle.net/10754/622768
UR - http://onlinelibrary.wiley.com/doi/10.1002/chem.201605450/full
UR - http://www.scopus.com/inward/record.url?scp=85007273867&partnerID=8YFLogxK
U2 - 10.1002/chem.201605450
DO - 10.1002/chem.201605450
M3 - Article
C2 - 27902876
SN - 0947-6539
VL - 23
SP - 798
EP - 801
JO - Chemistry - A European Journal
JF - Chemistry - A European Journal
IS - 4
ER -