Asymmetric synthesis of indolines by catalytic enantioselective reduction of 3H-indoles

Magnus Rueping; Claus Brinkmann; Andrey P. Antonchick; Iuliana Atodiresei

doi:10.1021/ol1019234

Asymmetric synthesis of indolines by catalytic enantioselective reduction of 3H-indoles

Magnus Rueping^*, Claus Brinkmann, Andrey P. Antonchick, Iuliana Atodiresei

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

108 Scopus citations

Abstract

A highly enantioselective metal-free reduction of 3H-indoles has been developed. This Brønsted acid catalyzed transfer hydrogenation of indole derivatives with Hantzsch dihydropyridine as the hydrogen source constitutes an efficient method for the synthesis of various optically active indolines with high enantioselectivities.

Original language	English (US)
Pages (from-to)	4604-4607
Number of pages	4
Journal	Organic Letters
Volume	12
Issue number	20
DOIs	https://doi.org/10.1021/ol1019234
State	Published - Oct 15 2010
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol1019234

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@article{818ec2d7957c43ee87546aedb19c6346,

title = "Asymmetric synthesis of indolines by catalytic enantioselective reduction of 3H-indoles",

abstract = "A highly enantioselective metal-free reduction of 3H-indoles has been developed. This Br{\o}nsted acid catalyzed transfer hydrogenation of indole derivatives with Hantzsch dihydropyridine as the hydrogen source constitutes an efficient method for the synthesis of various optically active indolines with high enantioselectivities.",

author = "Magnus Rueping and Claus Brinkmann and Antonchick, {Andrey P.} and Iuliana Atodiresei",

year = "2010",

month = oct,

day = "15",

doi = "10.1021/ol1019234",

language = "English (US)",

volume = "12",

pages = "4604--4607",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

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T1 - Asymmetric synthesis of indolines by catalytic enantioselective reduction of 3H-indoles

AU - Rueping, Magnus

AU - Brinkmann, Claus

AU - Antonchick, Andrey P.

AU - Atodiresei, Iuliana

PY - 2010/10/15

Y1 - 2010/10/15

N2 - A highly enantioselective metal-free reduction of 3H-indoles has been developed. This Brønsted acid catalyzed transfer hydrogenation of indole derivatives with Hantzsch dihydropyridine as the hydrogen source constitutes an efficient method for the synthesis of various optically active indolines with high enantioselectivities.

AB - A highly enantioselective metal-free reduction of 3H-indoles has been developed. This Brønsted acid catalyzed transfer hydrogenation of indole derivatives with Hantzsch dihydropyridine as the hydrogen source constitutes an efficient method for the synthesis of various optically active indolines with high enantioselectivities.

UR - http://www.scopus.com/inward/record.url?scp=77957856021&partnerID=8YFLogxK

U2 - 10.1021/ol1019234

DO - 10.1021/ol1019234

M3 - Article

C2 - 20857958

AN - SCOPUS:77957856021

SN - 1523-7060

VL - 12

SP - 4604

EP - 4607

JO - Organic Letters

JF - Organic Letters

IS - 20

ER -

Asymmetric synthesis of indolines by catalytic enantioselective reduction of 3H-indoles

Abstract

ASJC Scopus subject areas

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