Asymmetric Organocatalysis and Photoredox Catalysis for the α-Functionalization of Tetrahydroisoquinolines

Hong Hou, Shaoqun Zhu, Iuliana Atodiresei, Magnus Rueping*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


The asymmetric α-alkylation of tetrahydroisoquinolines with cyclic ketones has been accomplished in the presence of a combined catalytic system consisting of a visible-light photoredox catalyst and a chiral primary amine organocatalyst. The desired products were obtained in good yields, high enantioselectivity, and good to excellent diastereoselectivity. (PC: photoredox cycle, EN: enamine cycle).

Original languageEnglish (US)
Pages (from-to)1277-1280
Number of pages4
JournalEuropean Journal of Organic Chemistry
Issue number10
StatePublished - Mar 14 2018

Bibliographical note

Publisher Copyright:
© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim


  • Alkylation
  • Cyclic ketones
  • Organocatalysis
  • Photocatalysis
  • Tetrahydroisoquinolines

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry


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