The asymmetric α-alkylation of tetrahydroisoquinolines with cyclic ketones has been accomplished in the presence of a combined catalytic system consisting of a visible-light photoredox catalyst and a chiral primary amine organocatalyst. The desired products were obtained in good yields, high enantioselectivity, and good to excellent diastereoselectivity. (PC: photoredox cycle, EN: enamine cycle).
Bibliographical notePublisher Copyright:
© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
- Cyclic ketones
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry
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CCDC 1819590: Experimental Crystal Structure Determination : (S)-2-[(R)-2-(4-bromophenyl)-1,2,3,4-tetrahydroisoquinolin-1-yl]cyclohexan-1-one
Hou, H. (Creator), Zhu, S. (Creator), Atodiresei, I. (Creator), Rueping, M. (Creator), Hou, H. (Creator), Zhu, S. (Creator) & Atodiresei, I. (Creator), Cambridge Crystallographic Data Centre, Mar 22 2018