Asymmetric calcium catalysis: Highly enantioselective carbonyl-ene and friedel-crafts reactions for the synthesis of quaternary α-hydroxy esters bearing a trifluoromethyl group

Magnus Rueping; Teerawut Bootwicha; Supakeat Kambutong; Erli Sugiono

doi:10.1002/asia.201200063

Asymmetric calcium catalysis: Highly enantioselective carbonyl-ene and friedel-crafts reactions for the synthesis of quaternary α-hydroxy esters bearing a trifluoromethyl group

Magnus Rueping^*, Teerawut Bootwicha, Supakeat Kambutong, Erli Sugiono

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

Enantioselective calcium-catalyzed addition reactions of styrene and indole derivatives with trifluoropyruvates have been developed. The alkaline-earth metal-catalyzed reactions proceed smoothly to afford the corresponding products in high yields and with good to excellent enantioselectivities under mild reaction conditions.

Original language	English (US)
Pages (from-to)	1195-1198
Number of pages	4
Journal	Chemistry - An Asian Journal
Volume	7
Issue number	6
DOIs	https://doi.org/10.1002/asia.201200063
State	Published - Jun 2012
Externally published	Yes

Keywords

1,2-addition reactions
asymmetric synthesis
brø nsted acids
calcium
chirality

ASJC Scopus subject areas

Biochemistry
Organic Chemistry

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10.1002/asia.201200063

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title = "Asymmetric calcium catalysis: Highly enantioselective carbonyl-ene and friedel-crafts reactions for the synthesis of quaternary α-hydroxy esters bearing a trifluoromethyl group",

abstract = "Enantioselective calcium-catalyzed addition reactions of styrene and indole derivatives with trifluoropyruvates have been developed. The alkaline-earth metal-catalyzed reactions proceed smoothly to afford the corresponding products in high yields and with good to excellent enantioselectivities under mild reaction conditions.",

keywords = "1,2-addition reactions, asymmetric synthesis, br{\o} nsted acids, calcium, chirality",

author = "Magnus Rueping and Teerawut Bootwicha and Supakeat Kambutong and Erli Sugiono",

year = "2012",

month = jun,

doi = "10.1002/asia.201200063",

language = "English (US)",

volume = "7",

pages = "1195--1198",

journal = "Chemistry - An Asian Journal",

issn = "1861-4728",

publisher = "Wiley",

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Asymmetric calcium catalysis: Highly enantioselective carbonyl-ene and friedel-crafts reactions for the synthesis of quaternary α-hydroxy esters bearing a trifluoromethyl group. / Rueping, Magnus; Bootwicha, Teerawut; Kambutong, Supakeat et al.
In: Chemistry - An Asian Journal, Vol. 7, No. 6, 06.2012, p. 1195-1198.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Asymmetric calcium catalysis

T2 - Highly enantioselective carbonyl-ene and friedel-crafts reactions for the synthesis of quaternary α-hydroxy esters bearing a trifluoromethyl group

AU - Rueping, Magnus

AU - Bootwicha, Teerawut

AU - Kambutong, Supakeat

AU - Sugiono, Erli

PY - 2012/6

Y1 - 2012/6

N2 - Enantioselective calcium-catalyzed addition reactions of styrene and indole derivatives with trifluoropyruvates have been developed. The alkaline-earth metal-catalyzed reactions proceed smoothly to afford the corresponding products in high yields and with good to excellent enantioselectivities under mild reaction conditions.

AB - Enantioselective calcium-catalyzed addition reactions of styrene and indole derivatives with trifluoropyruvates have been developed. The alkaline-earth metal-catalyzed reactions proceed smoothly to afford the corresponding products in high yields and with good to excellent enantioselectivities under mild reaction conditions.

KW - 1,2-addition reactions

KW - asymmetric synthesis

KW - brø nsted acids

KW - calcium

KW - chirality

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U2 - 10.1002/asia.201200063

DO - 10.1002/asia.201200063

M3 - Article

C2 - 22438311

AN - SCOPUS:84861566527

SN - 1861-4728

VL - 7

SP - 1195

EP - 1198

JO - Chemistry - An Asian Journal

JF - Chemistry - An Asian Journal

IS - 6

ER -

Asymmetric calcium catalysis: Highly enantioselective carbonyl-ene and friedel-crafts reactions for the synthesis of quaternary α-hydroxy esters bearing a trifluoromethyl group

Abstract

Keywords

ASJC Scopus subject areas

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