Association of candidate genes with phenotypic traits relevant to anorexia nervosa

Tammy L. Root; Jin P. Szatkiewicz; Charles R. Jonassaint; Laura M. Thornton; Andrea Poyastro Pinheiro; Michael Strober; Cinnamon Bloss; Wade Berrettini; Nicholas J. Schork; Walter H. Kaye; Andrew W. Bergen; Pierre Magistretti; Harry Brandt; Steve Crawford; Scott Crow; Manfred M. Fichter; David Goldman; Katherine A. Halmi; Craig Johnson; Allan S. Kaplan; Pamela K. Keel; Kelly L. Klump; Maria La Via; James E. Mitchell; Alessandro Rotondo; Janet Treasure; D. Blake Woodside; Cynthia M. Bulik

doi:10.1002/erv.1138

Association of candidate genes with phenotypic traits relevant to anorexia nervosa

Tammy L. Root, Jin P. Szatkiewicz, Charles R. Jonassaint, Laura M. Thornton, Andrea Poyastro Pinheiro, Michael Strober, Cinnamon Bloss, Wade Berrettini, Nicholas J. Schork, Walter H. Kaye, Andrew W. Bergen, Pierre Magistretti, Harry Brandt, Steve Crawford, Scott Crow, Manfred M. Fichter, David Goldman, Katherine A. Halmi, Craig Johnson, Allan S. KaplanPamela K. Keel, Kelly L. Klump, Maria La Via, James E. Mitchell, Alessandro Rotondo, Janet Treasure, D. Blake Woodside, Cynthia M. Bulik^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

This analysis is a follow-up to an earlier investigation of 182 genes selected as likely candidate genetic variations conferring susceptibility to anorexia nervosa (AN). As those initial case-control results revealed no statistically significant differences in single nucleotide polymorphisms, herein, we investigate alternative phenotypes associated with AN. In 1762 females, using regression analyses, we examined the following: (i) lowest illness-related attained body mass index; (ii) age at menarche; (iii) drive for thinness; (iv) body dissatisfaction; (v) trait anxiety; (vi) concern over mistakes; and (vii) the anticipatory worry and pessimism versus uninhibited optimism subscale of the harm avoidance scale. After controlling for multiple comparisons, no statistically significant results emerged. Although results must be viewed in the context of limitations of statistical power, the approach illustrates a means of potentially identifying genetic variants conferring susceptibility to AN because less complex phenotypes associated with AN are more proximal to the genotype and may be influenced by fewer genes.

Original language	English (US)
Pages (from-to)	487-493
Number of pages	7
Journal	European Eating Disorders Review
Volume	19
Issue number	6
DOIs	https://doi.org/10.1002/erv.1138
State	Published - Nov 2011
Externally published	Yes

Keywords

association studies
covariates
eating disorders
genetic
personality

ASJC Scopus subject areas

Clinical Psychology
Psychiatry and Mental health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/erv.1138

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Root, T. L., Szatkiewicz, J. P., Jonassaint, C. R., Thornton, L. M., Pinheiro, A. P., Strober, M., Bloss, C., Berrettini, W., Schork, N. J., Kaye, W. H., Bergen, A. W., Magistretti, P., Brandt, H., Crawford, S., Crow, S., Fichter, M. M., Goldman, D., Halmi, K. A., Johnson, C., ... Bulik, C. M. (2011). Association of candidate genes with phenotypic traits relevant to anorexia nervosa. European Eating Disorders Review, 19(6), 487-493. https://doi.org/10.1002/erv.1138

@article{088b079752274dac999445cdd84026a7,

title = "Association of candidate genes with phenotypic traits relevant to anorexia nervosa",

abstract = "This analysis is a follow-up to an earlier investigation of 182 genes selected as likely candidate genetic variations conferring susceptibility to anorexia nervosa (AN). As those initial case-control results revealed no statistically significant differences in single nucleotide polymorphisms, herein, we investigate alternative phenotypes associated with AN. In 1762 females, using regression analyses, we examined the following: (i) lowest illness-related attained body mass index; (ii) age at menarche; (iii) drive for thinness; (iv) body dissatisfaction; (v) trait anxiety; (vi) concern over mistakes; and (vii) the anticipatory worry and pessimism versus uninhibited optimism subscale of the harm avoidance scale. After controlling for multiple comparisons, no statistically significant results emerged. Although results must be viewed in the context of limitations of statistical power, the approach illustrates a means of potentially identifying genetic variants conferring susceptibility to AN because less complex phenotypes associated with AN are more proximal to the genotype and may be influenced by fewer genes.",

keywords = "association studies, covariates, eating disorders, genetic, personality",

author = "Root, {Tammy L.} and Szatkiewicz, {Jin P.} and Jonassaint, {Charles R.} and Thornton, {Laura M.} and Pinheiro, {Andrea Poyastro} and Michael Strober and Cinnamon Bloss and Wade Berrettini and Schork, {Nicholas J.} and Kaye, {Walter H.} and Bergen, {Andrew W.} and Pierre Magistretti and Harry Brandt and Steve Crawford and Scott Crow and Fichter, {Manfred M.} and David Goldman and Halmi, {Katherine A.} and Craig Johnson and Kaplan, {Allan S.} and Keel, {Pamela K.} and Klump, {Kelly L.} and {La Via}, Maria and Mitchell, {James E.} and Alessandro Rotondo and Janet Treasure and Woodside, {D. Blake} and Bulik, {Cynthia M.}",

year = "2011",

month = nov,

doi = "10.1002/erv.1138",

language = "English (US)",

volume = "19",

pages = "487--493",

journal = "European Eating Disorders Review",

issn = "1072-4133",

publisher = "John Wiley and Sons Ltd",

number = "6",

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Root, TL, Szatkiewicz, JP, Jonassaint, CR, Thornton, LM, Pinheiro, AP, Strober, M, Bloss, C, Berrettini, W, Schork, NJ, Kaye, WH, Bergen, AW, Magistretti, P, Brandt, H, Crawford, S, Crow, S, Fichter, MM, Goldman, D, Halmi, KA, Johnson, C, Kaplan, AS, Keel, PK, Klump, KL, La Via, M, Mitchell, JE, Rotondo, A, Treasure, J, Woodside, DB & Bulik, CM 2011, 'Association of candidate genes with phenotypic traits relevant to anorexia nervosa', European Eating Disorders Review, vol. 19, no. 6, pp. 487-493. https://doi.org/10.1002/erv.1138

TY - JOUR

T1 - Association of candidate genes with phenotypic traits relevant to anorexia nervosa

AU - Root, Tammy L.

AU - Szatkiewicz, Jin P.

AU - Jonassaint, Charles R.

AU - Thornton, Laura M.

AU - Pinheiro, Andrea Poyastro

AU - Strober, Michael

AU - Bloss, Cinnamon

AU - Berrettini, Wade

AU - Schork, Nicholas J.

AU - Kaye, Walter H.

AU - Bergen, Andrew W.

AU - Magistretti, Pierre

AU - Brandt, Harry

AU - Crawford, Steve

AU - Crow, Scott

AU - Fichter, Manfred M.

AU - Goldman, David

AU - Halmi, Katherine A.

AU - Johnson, Craig

AU - Kaplan, Allan S.

AU - Keel, Pamela K.

AU - Klump, Kelly L.

AU - La Via, Maria

AU - Mitchell, James E.

AU - Rotondo, Alessandro

AU - Treasure, Janet

AU - Woodside, D. Blake

AU - Bulik, Cynthia M.

PY - 2011/11

Y1 - 2011/11

N2 - This analysis is a follow-up to an earlier investigation of 182 genes selected as likely candidate genetic variations conferring susceptibility to anorexia nervosa (AN). As those initial case-control results revealed no statistically significant differences in single nucleotide polymorphisms, herein, we investigate alternative phenotypes associated with AN. In 1762 females, using regression analyses, we examined the following: (i) lowest illness-related attained body mass index; (ii) age at menarche; (iii) drive for thinness; (iv) body dissatisfaction; (v) trait anxiety; (vi) concern over mistakes; and (vii) the anticipatory worry and pessimism versus uninhibited optimism subscale of the harm avoidance scale. After controlling for multiple comparisons, no statistically significant results emerged. Although results must be viewed in the context of limitations of statistical power, the approach illustrates a means of potentially identifying genetic variants conferring susceptibility to AN because less complex phenotypes associated with AN are more proximal to the genotype and may be influenced by fewer genes.

AB - This analysis is a follow-up to an earlier investigation of 182 genes selected as likely candidate genetic variations conferring susceptibility to anorexia nervosa (AN). As those initial case-control results revealed no statistically significant differences in single nucleotide polymorphisms, herein, we investigate alternative phenotypes associated with AN. In 1762 females, using regression analyses, we examined the following: (i) lowest illness-related attained body mass index; (ii) age at menarche; (iii) drive for thinness; (iv) body dissatisfaction; (v) trait anxiety; (vi) concern over mistakes; and (vii) the anticipatory worry and pessimism versus uninhibited optimism subscale of the harm avoidance scale. After controlling for multiple comparisons, no statistically significant results emerged. Although results must be viewed in the context of limitations of statistical power, the approach illustrates a means of potentially identifying genetic variants conferring susceptibility to AN because less complex phenotypes associated with AN are more proximal to the genotype and may be influenced by fewer genes.

KW - association studies

KW - covariates

KW - eating disorders

KW - genetic

KW - personality

UR - http://www.scopus.com/inward/record.url?scp=80055002817&partnerID=8YFLogxK

U2 - 10.1002/erv.1138

DO - 10.1002/erv.1138

M3 - Article

C2 - 21780254

AN - SCOPUS:80055002817

SN - 1072-4133

VL - 19

SP - 487

EP - 493

JO - European Eating Disorders Review

JF - European Eating Disorders Review

IS - 6

ER -

Association of candidate genes with phenotypic traits relevant to anorexia nervosa

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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