Assessment of the EarlyCDT-Lung test as an early biomarker of lung cancer in ever-smokers: A retrospective nested case-control study in two prospective cohorts

Wendy Yi Ying Wu, Zahra Haider, Xiaoshuang Feng, Alicia K. Heath, Anne Tjønneland, Antonio Agudo, Giovanna Masala, Hilary A. Robbins, José María Huerta, Marcela Guevara, Matthias B. Schulze, Miguel Rodriguez-Barranco, Paolo Vineis, Rosario Tumino, Rudolf Kaaks, Renée T. Fortner, Sabina Sieri, Salvatore Panico, Therese Haugdahl Nøst, Torkjel M. SandangerTonje Braaten, Mattias Johansson, Beatrice Melin, Mikael Johansson

Research output: Contribution to journalArticlepeer-review

Abstract

The EarlyCDT-Lung test is a blood-based autoantibody assay intended to identify high-risk individuals for low-dose computed tomography lung cancer screening. However, there is a paucity of evidence on the performance of the EarlyCDT-Lung test in ever-smokers. We conducted a nested case-control study within two prospective cohorts to evaluate the risk-discriminatory performance of the EarlyCDT-Lung test using prediagnostic blood samples from 154 future lung cancer cases and 154 matched controls. Cases were selected from those who had ever smoked and had a prediagnostic blood sample
Original languageEnglish (US)
Pages (from-to)2002-2010
Number of pages9
JournalInternational Journal of Cancer
Volume152
Issue number9
DOIs
StatePublished - May 1 2023
Externally publishedYes

Bibliographical note

Generated from Scopus record by KAUST IRTS on 2023-09-21

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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