Aspergilones A and B, two benzylazaphilones with an unprecedented carbon skeleton from the gorgonian-derived fungus Aspergillus sp.

Chang Lun Shao, Chang Yun Wang, Mei Yan Wei, Yu Cheng Gu, Zhi Gang She, Pei-Yuan Qian, Yong Cheng Lin

Research output: Contribution to journalArticlepeer-review

67 Scopus citations

Abstract

Two novel benzylazaphilone derivatives with an unprecedented carbon skeleton, aspergilone A (1), and its symmetrical dimer with a unique methylene bridge, aspergilone B (2), have been isolated from the culture broth of a marine-derived fungus Aspergillus sp. from a gorgonian Dichotella gemmacea. Their structures and relative stereochemistries of 1 and 2 were elucidated using a combination of NMR spectroscopy and X-ray crystallography. Compound 1 not only exhibited in vitro selective cytotoxicity but also showed potent antifouling activity. © 2010 Elsevier Ltd. All rights reserved.
Original languageEnglish (US)
Pages (from-to)690-693
Number of pages4
JournalBioorganic & Medicinal Chemistry Letters
Volume21
Issue number2
DOIs
StatePublished - Jan 2011
Externally publishedYes

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: This work was supported by the National Natural Science Foundation of China (Nos. 30901879; 40976077; 40776073), the Research Fund for the Doctoral Program of Higher Education, Ministry of Education of China (No. 20090132110002), and the Basic Research Program of Science and Technology, Ministry of Science and Technology of China (No. 2007FY210500).
This publication acknowledges KAUST support, but has no KAUST affiliated authors.

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