Arabidopsis MAPKKK18 positively regulates drought stress resistance via downstream MAPKK3

Yuanyuan Li, Huixian Cai, Pu Liu, Chunyan Wang, Huiyang Gao, Changai Wu, Kang Yan, Shizhong Zhang, Jinguang Huang, Chengchao Zheng

Research output: Contribution to journalArticlepeer-review

73 Scopus citations

Abstract

Mitogen-activated protein kinase (MAPK) cascades are conserved and vital signaling components in the responses to various ambient stresses. Here, we report the identification of MAPKKK18, a drought resistance associated MAPK kinase kinase in Arabidopsis. The mapkkk18 knockout mutants displayed hypersensitivity to drought stress, whereas overaccumulation of MAPKKK18 in transgenic Arabidopsis plants significantly enhanced the resistance to drought. Expression pattern analysis revealed that the inducible expression of MAPKKK18 by osmotic stress was ABA and the canonical ABA signaling pathway dependent. Furthermore, MAPKKK18 mainly exerted its regulatory roles via downstream MAPKK3. These findings uncovered important roles for MAPKKK18 in drought resistance and expanded our understanding of the MAPK pathways in modulating abiotic stress responses.
Original languageEnglish (US)
Pages (from-to)292-297
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume484
Issue number2
DOIs
StatePublished - Feb 16 2017
Externally publishedYes

Bibliographical note

KAUST Repository Item: Exported on 2022-06-03
Acknowledgements: We thank Dr. Heribert Hirt (Center for Desert Agriculture, King Abdullah University of Science and Technology) for kindly providing us the MAPKKK18pro
This publication acknowledges KAUST support, but has no KAUST affiliated authors.

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology
  • Biophysics

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