Aquasomes - A nanoparticulate approach for the delivery of antigen

Amit K. Goyal, Kapil Khatri, Neeraj Mishra, Abhinav Mehta, Bhuvaneshwar Vaidya, Shailja Tiwari, Suresh Prasad Vyas

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

The development of compound that enhances immune responses to recombinant or synthetic epitopes is of considerable importance in vaccine research. Of the many different types of immunopotentiating compounds that have been researched, aquasomes are of considerable promise, because of their potency and adjuvanticity. Aquasomes were prepared by self-assembling of hydroxyapatite by co-precipitation method and thereafter preliminary coated with polyhydroxyl oligomers (cellobiose and trehalose) and subsequently adsorbed with bovine serum albumin (BSA) as a model antigen. The prepared systems were characterized for size, shape, antigen-loading efficiency, in vitro antigen stability, and in vivo performance. BSA-immobilized aquasomes were around 200 nm in diameter and spherical in shape and had approximately 20-30% BSA-loading efficiency. The immunological activity of the formulated aquasomes was compared with plain BSA and better results were observed. Studies also indicated that aquasome formulations could elicit combined T-helper 1 (Th1) and Th2 immune response. Copyright © Informa UK, Ltd.
Original languageEnglish (US)
Pages (from-to)1297-1305
Number of pages9
JournalDrug Development and Industrial Pharmacy
Volume34
Issue number12
DOIs
StatePublished - Dec 1 2008
Externally publishedYes

Bibliographical note

Generated from Scopus record by KAUST IRTS on 2023-10-12

ASJC Scopus subject areas

  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

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