Antioxidant enzymes expression in lymphocytes of patients undergoing carotid endarterectomy

Milan Obradovic; Sonja Zafirovic; Magbubah Essack; Jelena Dimitrov; Lada Zivkovic; Biljana Spremo-Potparevic; Djordje Radak; Vladimir B. Bajic; Esma R. Isenovic

doi:10.1016/j.mehy.2019.109419

Antioxidant enzymes expression in lymphocytes of patients undergoing carotid endarterectomy

Milan Obradovic, Sonja Zafirovic, Magbubah Essack, Jelena Dimitrov, Lada Zivkovic, Biljana Spremo-Potparevic, Djordje Radak, Vladimir B. Bajic, Esma R. Isenovic

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2 Scopus citations

Abstract

To remedy carotid artery stenosis and prevent stroke surgical intervention is commonly used, and the gold standard being carotid endarterectomy (CEA). During CEA cerebrovascular hemoglobin oxygen saturation decreases and when this decrease reaches critical levels it leads to cerebral hypoxia that causes neuronal damage. One of the proposed mechanism that affects changes during CEA and contribute to acute brain ischemia (ABI) is oxidative stress. The increased production of reactive oxygen species and reactive nitrogen species during ABI may cause an unregulated inflammatory response and further lead to structural and functional injury of neurons. Antioxidant activity are involved in the protection against neuronal damage after cerebral ischemia. We hypothesized that neuronal injury and poor outcomes in patients undergoing CEA may be results of oxidative stress that disturbed function of antioxidant enzymes and contributed to the DNA damage in lymphocytes.

Original language	English (US)
Pages (from-to)	109419
Journal	Medical Hypotheses
Volume	134
DOIs	https://doi.org/10.1016/j.mehy.2019.109419
State	Published - Oct 3 2019

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledged KAUST grant number(s): BAS/1/1606-01-01, FCC/1/1976-17-01, OSR#4129
Acknowledgements: This work was supported by Grants funded by the Ministry of Science, Education and Technological development, Republic of Serbia, No. 173033 (to E.R.I.), No. 41002 (to Dj.R.) and No. 173034 (to B.P.). The authors are grateful to the COST Action CA15132, ‘hCOMET’, for support. The research reported in this publication was also supported by the KAUST grant OSR#4129 (to E.R.I. and V.B.B.), which also supported M.O., and S.Z. V.B.B. has been supported by the KAUST Base Research Fund (BAS/1/1606-01-01), while V.B.B. and M.E. have been supported by KAUST Office of Sponsored Research (OSR) grant no. FCC/1/1976-17-01.

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10.1016/j.mehy.2019.109419

https://repository.kaust.edu.sa/bitstream/10754/658647/1/1-s2.0-S0306987719310497-main.pdf

Cite this

@article{cb46af65734047739296aacc2055aa6a,

title = "Antioxidant enzymes expression in lymphocytes of patients undergoing carotid endarterectomy",

abstract = "To remedy carotid artery stenosis and prevent stroke surgical intervention is commonly used, and the gold standard being carotid endarterectomy (CEA). During CEA cerebrovascular hemoglobin oxygen saturation decreases and when this decrease reaches critical levels it leads to cerebral hypoxia that causes neuronal damage. One of the proposed mechanism that affects changes during CEA and contribute to acute brain ischemia (ABI) is oxidative stress. The increased production of reactive oxygen species and reactive nitrogen species during ABI may cause an unregulated inflammatory response and further lead to structural and functional injury of neurons. Antioxidant activity are involved in the protection against neuronal damage after cerebral ischemia. We hypothesized that neuronal injury and poor outcomes in patients undergoing CEA may be results of oxidative stress that disturbed function of antioxidant enzymes and contributed to the DNA damage in lymphocytes.",

author = "Milan Obradovic and Sonja Zafirovic and Magbubah Essack and Jelena Dimitrov and Lada Zivkovic and Biljana Spremo-Potparevic and Djordje Radak and Bajic, {Vladimir B.} and Isenovic, {Esma R.}",

note = "KAUST Repository Item: Exported on 2020-10-01 Acknowledged KAUST grant number(s): BAS/1/1606-01-01, FCC/1/1976-17-01, OSR#4129 Acknowledgements: This work was supported by Grants funded by the Ministry of Science, Education and Technological development, Republic of Serbia, No. 173033 (to E.R.I.), No. 41002 (to Dj.R.) and No. 173034 (to B.P.). The authors are grateful to the COST Action CA15132, {\textquoteleft}hCOMET{\textquoteright}, for support. The research reported in this publication was also supported by the KAUST grant OSR#4129 (to E.R.I. and V.B.B.), which also supported M.O., and S.Z. V.B.B. has been supported by the KAUST Base Research Fund (BAS/1/1606-01-01), while V.B.B. and M.E. have been supported by KAUST Office of Sponsored Research (OSR) grant no. FCC/1/1976-17-01.",

year = "2019",

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doi = "10.1016/j.mehy.2019.109419",

language = "English (US)",

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T1 - Antioxidant enzymes expression in lymphocytes of patients undergoing carotid endarterectomy

AU - Obradovic, Milan

AU - Zafirovic, Sonja

AU - Essack, Magbubah

AU - Dimitrov, Jelena

AU - Zivkovic, Lada

AU - Spremo-Potparevic, Biljana

AU - Radak, Djordje

AU - Bajic, Vladimir B.

AU - Isenovic, Esma R.

N1 - KAUST Repository Item: Exported on 2020-10-01 Acknowledged KAUST grant number(s): BAS/1/1606-01-01, FCC/1/1976-17-01, OSR#4129 Acknowledgements: This work was supported by Grants funded by the Ministry of Science, Education and Technological development, Republic of Serbia, No. 173033 (to E.R.I.), No. 41002 (to Dj.R.) and No. 173034 (to B.P.). The authors are grateful to the COST Action CA15132, ‘hCOMET’, for support. The research reported in this publication was also supported by the KAUST grant OSR#4129 (to E.R.I. and V.B.B.), which also supported M.O., and S.Z. V.B.B. has been supported by the KAUST Base Research Fund (BAS/1/1606-01-01), while V.B.B. and M.E. have been supported by KAUST Office of Sponsored Research (OSR) grant no. FCC/1/1976-17-01.

PY - 2019/10/3

Y1 - 2019/10/3

N2 - To remedy carotid artery stenosis and prevent stroke surgical intervention is commonly used, and the gold standard being carotid endarterectomy (CEA). During CEA cerebrovascular hemoglobin oxygen saturation decreases and when this decrease reaches critical levels it leads to cerebral hypoxia that causes neuronal damage. One of the proposed mechanism that affects changes during CEA and contribute to acute brain ischemia (ABI) is oxidative stress. The increased production of reactive oxygen species and reactive nitrogen species during ABI may cause an unregulated inflammatory response and further lead to structural and functional injury of neurons. Antioxidant activity are involved in the protection against neuronal damage after cerebral ischemia. We hypothesized that neuronal injury and poor outcomes in patients undergoing CEA may be results of oxidative stress that disturbed function of antioxidant enzymes and contributed to the DNA damage in lymphocytes.

AB - To remedy carotid artery stenosis and prevent stroke surgical intervention is commonly used, and the gold standard being carotid endarterectomy (CEA). During CEA cerebrovascular hemoglobin oxygen saturation decreases and when this decrease reaches critical levels it leads to cerebral hypoxia that causes neuronal damage. One of the proposed mechanism that affects changes during CEA and contribute to acute brain ischemia (ABI) is oxidative stress. The increased production of reactive oxygen species and reactive nitrogen species during ABI may cause an unregulated inflammatory response and further lead to structural and functional injury of neurons. Antioxidant activity are involved in the protection against neuronal damage after cerebral ischemia. We hypothesized that neuronal injury and poor outcomes in patients undergoing CEA may be results of oxidative stress that disturbed function of antioxidant enzymes and contributed to the DNA damage in lymphocytes.

UR - http://hdl.handle.net/10754/658647

UR - https://linkinghub.elsevier.com/retrieve/pii/S0306987719310497

UR - http://www.scopus.com/inward/record.url?scp=85073096930&partnerID=8YFLogxK

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DO - 10.1016/j.mehy.2019.109419

M3 - Article

C2 - 31622925

SN - 0306-9877

VL - 134

SP - 109419

JO - Medical Hypotheses

JF - Medical Hypotheses

ER -

Antioxidant enzymes expression in lymphocytes of patients undergoing carotid endarterectomy

Abstract

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