Antifouling briarane type diterpenoids from South China Sea gorgonians Dichotella gemmacea

Jian Fan Sun, Zhuang Han, Xue Feng Zhou, Bin Yang, Xiuping Lin, Juan Liu, Yan Peng, Xian Wen Yang, Yonghong Liu

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


Our continued investigation on the South China Sea gorgonian Dichotella gemmacea led to the isolation of 16 new briarane-type diterpenoids, dichotellides F-U (1-16), along with 18 known analogues (17-34). Their structures were determined by MS, 1D and 2D NMR spectra analyses and by comparison with those reported in literature. The absolute configuration of 15 was confirmed by single-crystal X-ray diffraction data. The antifouling test showed that compounds 3, 4, 6-11, 16, and 23 had potent antifouling activities at nontoxic concentrations with EC50 values of 4.1, 1.82, 6.3, 7.6, 4.6, 1.2, 5.6, 0.79, 2.0, and 0.2 μg/mL, respectively. © 2012 Elsevier Ltd. All rights reserved.
Original languageEnglish (US)
Pages (from-to)871-880
Number of pages10
Issue number2
StatePublished - Jan 2013
Externally publishedYes

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: This study was supported by the National Basic Research Program of China (973 Program, Nos. 2010CB833800 and 2011CB915503), the National High Technology Research and Development Program (863 Program, 2012AA092104), Knowledge Innovation Program of Chinese Academy of Science (KSCX2-YW-G-073 and KSCX2-EW-G-12B), and National Natural Science Foundation of China (Nos. 30973679, 20902094, 21172230, 41176148, 21002110).Guangdong Province-CAS Joint Research Program (2011B0 90300023), Guangdong Province Marine and Fishery Special Project for Science and Technology Popularization (A201101F03), the start-up grant from Jiangsu University (11JDG1147).
This publication acknowledges KAUST support, but has no KAUST affiliated authors.


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