Antifouling Activity of Secondary Metabolites Isolated from Chinese Marine Organisms

Yong Xin Li; Hui Xian Wu; Ying Xu; Chang Lun Shao; Chang Yun Wang; Pei-Yuan Qian

doi:10.1007/s10126-013-9502-7

Antifouling Activity of Secondary Metabolites Isolated from Chinese Marine Organisms

Yong Xin Li, Hui Xian Wu, Ying Xu, Chang Lun Shao, Chang Yun Wang, Pei-Yuan Qian

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

Biofouling results in tremendous economic losses to maritime industries around the world. A recent global ban on the use of organotin compounds as antifouling agents has further raised demand for safe and effective antifouling compounds. In this study, 49 secondary metabolites, including diterpenoids, steroids, and polyketides, were isolated from soft corals, gorgonians, brown algae, and fungi collected along the coast of China, and their antifouling activity was tested against cyprids of the barnacle Balanus (Amphibalanus) amphitrite. Twenty of the compounds were found to inhibit larval settlement significantly at a concentration of 25 μg ml-1. Two briarane diterpenoids, juncin O (2) and juncenolide H (3), were the most promising non-toxic antilarval settlement candidates, with EC50 values less than 0.13 μg ml-1 and a safety ratio (LC50/EC50) higher than 400. A preliminary structure-activity relationships study indicated that both furanon and furan moieties are important for antifouling activity. Intriguingly, the presence of hydroxyls enhanced their antisettlement activity. © 2013 Springer Science+Business Media New York.

Original language	English (US)
Pages (from-to)	552-558
Number of pages	7
Journal	Marine Biotechnology
Volume	15
Issue number	5
DOIs	https://doi.org/10.1007/s10126-013-9502-7
State	Published - Apr 25 2013
Externally published	Yes

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledged KAUST grant number(s): SA-C0040, UK-C001
Acknowledgements: This study was supported by a research grant (DY125-15-T-02) from the China Ocean Mineral Resources Research and Development Association, a joint research grant from the Research Grants Council of the Hong Kong Special Administrative Region and the National Natural Science Foundation of China (N_HKUST602/09 and No. 41130858), and an award (SA-C0040/UK-C001) from King Abdullah University of Science and Technology (KAUST) granted to P.Y. Qian.
This publication acknowledges KAUST support, but has no KAUST affiliated authors.

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10.1007/s10126-013-9502-7

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title = "Antifouling Activity of Secondary Metabolites Isolated from Chinese Marine Organisms",

abstract = "Biofouling results in tremendous economic losses to maritime industries around the world. A recent global ban on the use of organotin compounds as antifouling agents has further raised demand for safe and effective antifouling compounds. In this study, 49 secondary metabolites, including diterpenoids, steroids, and polyketides, were isolated from soft corals, gorgonians, brown algae, and fungi collected along the coast of China, and their antifouling activity was tested against cyprids of the barnacle Balanus (Amphibalanus) amphitrite. Twenty of the compounds were found to inhibit larval settlement significantly at a concentration of 25 μg ml-1. Two briarane diterpenoids, juncin O (2) and juncenolide H (3), were the most promising non-toxic antilarval settlement candidates, with EC50 values less than 0.13 μg ml-1 and a safety ratio (LC50/EC50) higher than 400. A preliminary structure-activity relationships study indicated that both furanon and furan moieties are important for antifouling activity. Intriguingly, the presence of hydroxyls enhanced their antisettlement activity. {\textcopyright} 2013 Springer Science+Business Media New York.",

author = "Li, {Yong Xin} and Wu, {Hui Xian} and Ying Xu and Shao, {Chang Lun} and Wang, {Chang Yun} and Pei-Yuan Qian",

note = "KAUST Repository Item: Exported on 2020-10-01 Acknowledged KAUST grant number(s): SA-C0040, UK-C001 Acknowledgements: This study was supported by a research grant (DY125-15-T-02) from the China Ocean Mineral Resources Research and Development Association, a joint research grant from the Research Grants Council of the Hong Kong Special Administrative Region and the National Natural Science Foundation of China (N_HKUST602/09 and No. 41130858), and an award (SA-C0040/UK-C001) from King Abdullah University of Science and Technology (KAUST) granted to P.Y. Qian. This publication acknowledges KAUST support, but has no KAUST affiliated authors.",

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AU - Li, Yong Xin

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AU - Xu, Ying

AU - Shao, Chang Lun

AU - Wang, Chang Yun

AU - Qian, Pei-Yuan

N1 - KAUST Repository Item: Exported on 2020-10-01 Acknowledged KAUST grant number(s): SA-C0040, UK-C001 Acknowledgements: This study was supported by a research grant (DY125-15-T-02) from the China Ocean Mineral Resources Research and Development Association, a joint research grant from the Research Grants Council of the Hong Kong Special Administrative Region and the National Natural Science Foundation of China (N_HKUST602/09 and No. 41130858), and an award (SA-C0040/UK-C001) from King Abdullah University of Science and Technology (KAUST) granted to P.Y. Qian. This publication acknowledges KAUST support, but has no KAUST affiliated authors.

PY - 2013/4/25

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N2 - Biofouling results in tremendous economic losses to maritime industries around the world. A recent global ban on the use of organotin compounds as antifouling agents has further raised demand for safe and effective antifouling compounds. In this study, 49 secondary metabolites, including diterpenoids, steroids, and polyketides, were isolated from soft corals, gorgonians, brown algae, and fungi collected along the coast of China, and their antifouling activity was tested against cyprids of the barnacle Balanus (Amphibalanus) amphitrite. Twenty of the compounds were found to inhibit larval settlement significantly at a concentration of 25 μg ml-1. Two briarane diterpenoids, juncin O (2) and juncenolide H (3), were the most promising non-toxic antilarval settlement candidates, with EC50 values less than 0.13 μg ml-1 and a safety ratio (LC50/EC50) higher than 400. A preliminary structure-activity relationships study indicated that both furanon and furan moieties are important for antifouling activity. Intriguingly, the presence of hydroxyls enhanced their antisettlement activity. © 2013 Springer Science+Business Media New York.

AB - Biofouling results in tremendous economic losses to maritime industries around the world. A recent global ban on the use of organotin compounds as antifouling agents has further raised demand for safe and effective antifouling compounds. In this study, 49 secondary metabolites, including diterpenoids, steroids, and polyketides, were isolated from soft corals, gorgonians, brown algae, and fungi collected along the coast of China, and their antifouling activity was tested against cyprids of the barnacle Balanus (Amphibalanus) amphitrite. Twenty of the compounds were found to inhibit larval settlement significantly at a concentration of 25 μg ml-1. Two briarane diterpenoids, juncin O (2) and juncenolide H (3), were the most promising non-toxic antilarval settlement candidates, with EC50 values less than 0.13 μg ml-1 and a safety ratio (LC50/EC50) higher than 400. A preliminary structure-activity relationships study indicated that both furanon and furan moieties are important for antifouling activity. Intriguingly, the presence of hydroxyls enhanced their antisettlement activity. © 2013 Springer Science+Business Media New York.

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EP - 558

JO - Marine Biotechnology

JF - Marine Biotechnology

IS - 5

ER -

Antifouling Activity of Secondary Metabolites Isolated from Chinese Marine Organisms

Abstract

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