Analysis of lanthanide complex dendrimer conjugates for bimodal NIR and MRI imaging

Christopher M. Andolina; Piper J. Klemm; William C. Floyd; Jean M.J. Fréchet; Kenneth N. Raymond

doi:10.1021/ma302206g

Analysis of lanthanide complex dendrimer conjugates for bimodal NIR and MRI imaging

Christopher M. Andolina, Piper J. Klemm, William C. Floyd, Jean M.J. Fréchet, Kenneth N. Raymond^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

Advances in clinical diagnostic instrumentation have enabled some imaging modalities to be run concurrently. For diagnostic purposes, multimodal imaging can allow for rapid location and accurate identification of a patient's illness. The paramagnetic and near-infrared (NIR) properties of Dy(III) and Yb(III) are interesting candidates for the development of bimodal NIR and magnetic resonance imaging (MRI) contrast agents. To enhance their intrinsic bimodal properties, these lanthanides were chelated using the hexadentate-all-oxygen-donor-ligand TREN-bis(1-Me)-3,2-HOPO-TAM-NX (NX, where X = 1, 2, or 3) and subsequently conjugated to the esteramide dendrimer (EA) to improve bioavailability, solubility, and relaxivity. Of these new complexes synthesized and evaluated, DyN1-EA had the largest ionic T₁ relaxivity, 7.60 mM^-1 s^-1, while YbN3-EA had the largest ionic T₂ relaxivity with a NIR quantum yield of 0.17% when evaluated in mouse serum. This is the first Yb(III) bimodal NIR/T₂ MRI contrast agent of its kind evaluated.

Original language	English (US)
Pages (from-to)	8982-8990
Number of pages	9
Journal	Macromolecules
Volume	45
Issue number	22
DOIs	https://doi.org/10.1021/ma302206g
State	Published - Nov 27 2012

ASJC Scopus subject areas

Organic Chemistry
Polymers and Plastics
Inorganic Chemistry
Materials Chemistry

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title = "Analysis of lanthanide complex dendrimer conjugates for bimodal NIR and MRI imaging",

abstract = "Advances in clinical diagnostic instrumentation have enabled some imaging modalities to be run concurrently. For diagnostic purposes, multimodal imaging can allow for rapid location and accurate identification of a patient's illness. The paramagnetic and near-infrared (NIR) properties of Dy(III) and Yb(III) are interesting candidates for the development of bimodal NIR and magnetic resonance imaging (MRI) contrast agents. To enhance their intrinsic bimodal properties, these lanthanides were chelated using the hexadentate-all-oxygen-donor-ligand TREN-bis(1-Me)-3,2-HOPO-TAM-NX (NX, where X = 1, 2, or 3) and subsequently conjugated to the esteramide dendrimer (EA) to improve bioavailability, solubility, and relaxivity. Of these new complexes synthesized and evaluated, DyN1-EA had the largest ionic T1 relaxivity, 7.60 mM-1 s-1, while YbN3-EA had the largest ionic T2 relaxivity with a NIR quantum yield of 0.17% when evaluated in mouse serum. This is the first Yb(III) bimodal NIR/T2 MRI contrast agent of its kind evaluated.",

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AU - Floyd, William C.

AU - Fréchet, Jean M.J.

AU - Raymond, Kenneth N.

PY - 2012/11/27

Y1 - 2012/11/27

N2 - Advances in clinical diagnostic instrumentation have enabled some imaging modalities to be run concurrently. For diagnostic purposes, multimodal imaging can allow for rapid location and accurate identification of a patient's illness. The paramagnetic and near-infrared (NIR) properties of Dy(III) and Yb(III) are interesting candidates for the development of bimodal NIR and magnetic resonance imaging (MRI) contrast agents. To enhance their intrinsic bimodal properties, these lanthanides were chelated using the hexadentate-all-oxygen-donor-ligand TREN-bis(1-Me)-3,2-HOPO-TAM-NX (NX, where X = 1, 2, or 3) and subsequently conjugated to the esteramide dendrimer (EA) to improve bioavailability, solubility, and relaxivity. Of these new complexes synthesized and evaluated, DyN1-EA had the largest ionic T1 relaxivity, 7.60 mM-1 s-1, while YbN3-EA had the largest ionic T2 relaxivity with a NIR quantum yield of 0.17% when evaluated in mouse serum. This is the first Yb(III) bimodal NIR/T2 MRI contrast agent of its kind evaluated.

AB - Advances in clinical diagnostic instrumentation have enabled some imaging modalities to be run concurrently. For diagnostic purposes, multimodal imaging can allow for rapid location and accurate identification of a patient's illness. The paramagnetic and near-infrared (NIR) properties of Dy(III) and Yb(III) are interesting candidates for the development of bimodal NIR and magnetic resonance imaging (MRI) contrast agents. To enhance their intrinsic bimodal properties, these lanthanides were chelated using the hexadentate-all-oxygen-donor-ligand TREN-bis(1-Me)-3,2-HOPO-TAM-NX (NX, where X = 1, 2, or 3) and subsequently conjugated to the esteramide dendrimer (EA) to improve bioavailability, solubility, and relaxivity. Of these new complexes synthesized and evaluated, DyN1-EA had the largest ionic T1 relaxivity, 7.60 mM-1 s-1, while YbN3-EA had the largest ionic T2 relaxivity with a NIR quantum yield of 0.17% when evaluated in mouse serum. This is the first Yb(III) bimodal NIR/T2 MRI contrast agent of its kind evaluated.

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Analysis of lanthanide complex dendrimer conjugates for bimodal NIR and MRI imaging

Abstract

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