Analysis of human papillomavirus 16 variants and risk for cervical cancer in Chinese population

Dong Hang, Yin Yin, Jing Han, Jie Jiang, Hongxqia Ma, Shuanghua Xie, Xiaoshuang Feng, Kai Zhang, Zhibin Hu, Hongbing Shen, Gary M. Clifford, Min Dai, Ni Li

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

HPV16 is the most carcinogenic HPV type, but only a minority of HPV16 infections progress to cancer. Intratype genetic variants of HPV16 have been suggested to confer differential carcinogenicity. To investigate risk implications of HPV16 variants among Chinese women, a case-control study was conducted with 298 cervical cancer patients and 85 controls (all HPV16-positive). HPV16 isolates were predominantly of the A variant lineage, and variants of A4 (previously named "Asian") sublineage were common. A4/Asian variants were significantly associated with increased risk of cervical cancer compared to A1-3 (OR=1.72, 95% CI=1.04-2.85). Furthermore, a meta-analysis including 703 cases and 323 controls from East Asia confirmed the association (OR=2.82, 95% CI=1.44-5.52). In conclusion, A4 variants appear to predict higher risk of cervical cancer among HPV16-positive women, which may provide clues to the genetic basis of differences in the carcinogenicity of HPV16 variants.
Original languageEnglish (US)
Pages (from-to)156-161
Number of pages6
JournalVirology
Volume488
DOIs
StatePublished - Jan 15 2016
Externally publishedYes

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Generated from Scopus record by KAUST IRTS on 2023-09-21

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