TY - JOUR
T1 - Analysis of human papillomavirus 16 variants and risk for cervical cancer in Chinese population
AU - Hang, Dong
AU - Yin, Yin
AU - Han, Jing
AU - Jiang, Jie
AU - Ma, Hongxqia
AU - Xie, Shuanghua
AU - Feng, Xiaoshuang
AU - Zhang, Kai
AU - Hu, Zhibin
AU - Shen, Hongbing
AU - Clifford, Gary M.
AU - Dai, Min
AU - Li, Ni
N1 - Generated from Scopus record by KAUST IRTS on 2023-09-21
PY - 2016/1/15
Y1 - 2016/1/15
N2 - HPV16 is the most carcinogenic HPV type, but only a minority of HPV16 infections progress to cancer. Intratype genetic variants of HPV16 have been suggested to confer differential carcinogenicity. To investigate risk implications of HPV16 variants among Chinese women, a case-control study was conducted with 298 cervical cancer patients and 85 controls (all HPV16-positive). HPV16 isolates were predominantly of the A variant lineage, and variants of A4 (previously named "Asian") sublineage were common. A4/Asian variants were significantly associated with increased risk of cervical cancer compared to A1-3 (OR=1.72, 95% CI=1.04-2.85). Furthermore, a meta-analysis including 703 cases and 323 controls from East Asia confirmed the association (OR=2.82, 95% CI=1.44-5.52). In conclusion, A4 variants appear to predict higher risk of cervical cancer among HPV16-positive women, which may provide clues to the genetic basis of differences in the carcinogenicity of HPV16 variants.
AB - HPV16 is the most carcinogenic HPV type, but only a minority of HPV16 infections progress to cancer. Intratype genetic variants of HPV16 have been suggested to confer differential carcinogenicity. To investigate risk implications of HPV16 variants among Chinese women, a case-control study was conducted with 298 cervical cancer patients and 85 controls (all HPV16-positive). HPV16 isolates were predominantly of the A variant lineage, and variants of A4 (previously named "Asian") sublineage were common. A4/Asian variants were significantly associated with increased risk of cervical cancer compared to A1-3 (OR=1.72, 95% CI=1.04-2.85). Furthermore, a meta-analysis including 703 cases and 323 controls from East Asia confirmed the association (OR=2.82, 95% CI=1.44-5.52). In conclusion, A4 variants appear to predict higher risk of cervical cancer among HPV16-positive women, which may provide clues to the genetic basis of differences in the carcinogenicity of HPV16 variants.
UR - https://linkinghub.elsevier.com/retrieve/pii/S0042682215004882
UR - http://www.scopus.com/inward/record.url?scp=84948748722&partnerID=8YFLogxK
U2 - 10.1016/j.virol.2015.11.016
DO - 10.1016/j.virol.2015.11.016
M3 - Article
SN - 0042-6822
VL - 488
SP - 156
EP - 161
JO - Virology
JF - Virology
ER -
