Abstract
For decades, lipid droplets have been considered as the main cellular organelles involved in the fat storage, because of their lipid composition. However, in recent years, some new and totally unexpected roles have been discovered for them: (i) they are active sites for synthesis and storage of inflammatory mediators, and (ii) they are key players in cancer cells and tissues, especially in cancer stem cells. In this review, we summarize the main concepts related to the lipid droplet structure and function and their involvement in inflammatory and cancer processes.
Original language | English (US) |
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Pages (from-to) | 1-17 |
Number of pages | 17 |
Journal | Stem Cells International |
Volume | 2017 |
DOIs | |
State | Published - Aug 13 2017 |
Bibliographical note
KAUST Repository Item: Exported on 2020-10-01Acknowledgements: The authors acknowledge financial support from KAUST Baseline Research Funds (BAS/1-1064-01-01 and BAS/1-1066-01-01) to C. Liberale and A. Falqui, respectively, and from KAUST start-up funding (Project no. GR-2010-2320665) to E. Di Fabrizio.