An investigation of indirect effects of personality features on anorexia nervosa severity through interoceptive dysfunction in individuals with lifetime anorexia nervosa diagnoses

Mary E. Duffy; Megan L. Rogers; Thomas E. Joiner; Andrew W. Bergen; Wade Berrettini; Cynthia M. Bulik; Harry Brandt; Steven Crawford; Scott Crow; Manfred Fichter; Katherine Halmi; Allan S. Kaplan; Kelly L. Klump; Lisa Lilenfeld; Pierre J. Magistretti; James Mitchell; Nicholas J. Schork; Michael Strober; Laura M. Thornton; Janet Treasure; Blake Woodside; Walter H. Kaye; Pamela K. Keel

doi:10.1002/eat.23008

An investigation of indirect effects of personality features on anorexia nervosa severity through interoceptive dysfunction in individuals with lifetime anorexia nervosa diagnoses

Mary E. Duffy, Megan L. Rogers, Thomas E. Joiner, Andrew W. Bergen, Wade Berrettini, Cynthia M. Bulik, Harry Brandt, Steven Crawford, Scott Crow, Manfred Fichter, Katherine Halmi, Allan S. Kaplan, Kelly L. Klump, Lisa Lilenfeld, Pierre J. Magistretti, James Mitchell, Nicholas J. Schork, Michael Strober, Laura M. Thornton, Janet TreasureBlake Woodside, Walter H. Kaye^*, Pamela K. Keel

^*Corresponding author for this work

Biological, Environmental Sciences and Engineering

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Objective: This study examined a hypothesized pathway by which interoceptive dysfunction accounted for associations between personality features (harm avoidance, self-directedness, and perfectionism) and anorexia nervosa (AN) severity (indicated by drive for thinness, eating disorder-related preoccupations and rituals, and body mass index). Method: The study sample (n = 270, mean age = 28.47, 95.2% female, 98% White/Caucasian) consisted of probands and biological relatives who met DSM-IV criteria for lifetime diagnoses of AN (omitting criterion D, amenorrhea) drawn from the Price Foundation Anorexia Nervosa Affected Relative Pairs Study (AN-ARP). Participants completed measures assessing personality, interoceptive dysfunction, and eating pathology. Results: Associations between personality features of low self-directedness and high perfectionism and indicators of AN severity (drive for thinness and eating disorder-related preoccupations and rituals) were significant, as were the hypothesized indirect pathways through interoceptive dysfunction. Neither harm avoidance nor body mass index was significantly related to other study variables, and the proposed indirect pathways involving these variables were not significant. Discussion: Findings suggest that certain personality features may relate to AN severity, in part, through their associations with interoceptive dysfunction. Future research should examine prospective associations and the value of interventions targeting interoceptive dysfunction for interrupting the link between personality and AN severity.

Original language	English (US)
Pages (from-to)	200-205
Number of pages	6
Journal	International Journal of Eating Disorders
Volume	52
Issue number	2
DOIs	https://doi.org/10.1002/eat.23008
State	Published - Feb 2019

Bibliographical note

Funding Information:
This material is based upon work supported by the National Science Foundation Graduate Research Fellowship Program under Grant No. NSF 1449440. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the National Science Foundation. This project was also in part supported by the Military Suicide Research Consortium (MSRC), an effort supported by the Department of Defense (W81XWH-10-2-0181; W81XWH-16-2-0003). Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the Military Suicide Research Consortium or the Department of Defense. This work was also financially supported by the Price Foundation of Geneva, Switzerland. Dr. Bulik acknowledges funding from the Swedish Research Council (VR Dnr: 538-2013-8864). The funding sources had no role in the conduct of the current research or preparation of the manuscript.

Funding Information:
information National Science Foundation, Grant/Award Number: NSF 1449440; Price Foundation of Geneva, Switzerland; Military Suicide Research Consortium, U.S. Department of Defense, Grant/Award Numbers: W81XWH-10-2-0181, W81XWH-16-2-0003; Vetenskapsrådet, Grant/Award Number: VR Dnr: 538-2013-8864; Swedish Research Council, Grant/Award Number: VR Dnr: 538-2013-8864This material is based upon work supported by the National Science Foundation Graduate Research Fellowship Program under Grant No. NSF 1449440. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the National Science Foundation. This project was also in part supported by the Military Suicide Research Consortium (MSRC), an effort supported by the Department of Defense (W81XWH-10-2-0181; W81XWH-16-2-0003). Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the Military Suicide Research Consortium or the Department of Defense. This work was also financially supported by the Price Foundation of Geneva, Switzerland. Dr. Bulik acknowledges funding from the Swedish Research Council (VR Dnr: 538-2013-8864). The funding sources had no role in the conduct of the current research or preparation of the manuscript.

Funding Information:
National Science Foundation, Grant/Award Number: NSF 1449440; Price Foundation of Geneva, Switzerland; Military Suicide Research Consortium, U.S. Department of Defense, Grant/Award Numbers: W81XWH-10-2-0181, W81XWH-16-2-0003; Vetenskapsrådet, Grant/Award Number: VR Dnr: 538-2013-8864; Swedish Research Council, Grant/Award Number: VR Dnr: 538-2013-8864

Publisher Copyright:
© 2019 Wiley Periodicals, Inc.

Keywords

anorexia nervosa
body mass index
feeding and eating disorders
perfectionism
personality
thinness

ASJC Scopus subject areas

Psychiatry and Mental health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/eat.23008

Cite this

Duffy, M. E., Rogers, M. L., Joiner, T. E., Bergen, A. W., Berrettini, W., Bulik, C. M., Brandt, H., Crawford, S., Crow, S., Fichter, M., Halmi, K., Kaplan, A. S., Klump, K. L., Lilenfeld, L., Magistretti, P. J., Mitchell, J., Schork, N. J., Strober, M., Thornton, L. M., ... Keel, P. K. (2019). An investigation of indirect effects of personality features on anorexia nervosa severity through interoceptive dysfunction in individuals with lifetime anorexia nervosa diagnoses. International Journal of Eating Disorders, 52(2), 200-205. https://doi.org/10.1002/eat.23008

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title = "An investigation of indirect effects of personality features on anorexia nervosa severity through interoceptive dysfunction in individuals with lifetime anorexia nervosa diagnoses",

abstract = "Objective: This study examined a hypothesized pathway by which interoceptive dysfunction accounted for associations between personality features (harm avoidance, self-directedness, and perfectionism) and anorexia nervosa (AN) severity (indicated by drive for thinness, eating disorder-related preoccupations and rituals, and body mass index). Method: The study sample (n = 270, mean age = 28.47, 95.2% female, 98% White/Caucasian) consisted of probands and biological relatives who met DSM-IV criteria for lifetime diagnoses of AN (omitting criterion D, amenorrhea) drawn from the Price Foundation Anorexia Nervosa Affected Relative Pairs Study (AN-ARP). Participants completed measures assessing personality, interoceptive dysfunction, and eating pathology. Results: Associations between personality features of low self-directedness and high perfectionism and indicators of AN severity (drive for thinness and eating disorder-related preoccupations and rituals) were significant, as were the hypothesized indirect pathways through interoceptive dysfunction. Neither harm avoidance nor body mass index was significantly related to other study variables, and the proposed indirect pathways involving these variables were not significant. Discussion: Findings suggest that certain personality features may relate to AN severity, in part, through their associations with interoceptive dysfunction. Future research should examine prospective associations and the value of interventions targeting interoceptive dysfunction for interrupting the link between personality and AN severity.",

keywords = "anorexia nervosa, body mass index, feeding and eating disorders, perfectionism, personality, thinness",

author = "Duffy, {Mary E.} and Rogers, {Megan L.} and Joiner, {Thomas E.} and Bergen, {Andrew W.} and Wade Berrettini and Bulik, {Cynthia M.} and Harry Brandt and Steven Crawford and Scott Crow and Manfred Fichter and Katherine Halmi and Kaplan, {Allan S.} and Klump, {Kelly L.} and Lisa Lilenfeld and Magistretti, {Pierre J.} and James Mitchell and Schork, {Nicholas J.} and Michael Strober and Thornton, {Laura M.} and Janet Treasure and Blake Woodside and Kaye, {Walter H.} and Keel, {Pamela K.}",

note = "Funding Information: This material is based upon work supported by the National Science Foundation Graduate Research Fellowship Program under Grant No. NSF 1449440. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the National Science Foundation. This project was also in part supported by the Military Suicide Research Consortium (MSRC), an effort supported by the Department of Defense (W81XWH-10-2-0181; W81XWH-16-2-0003). Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the Military Suicide Research Consortium or the Department of Defense. This work was also financially supported by the Price Foundation of Geneva, Switzerland. Dr. Bulik acknowledges funding from the Swedish Research Council (VR Dnr: 538-2013-8864). The funding sources had no role in the conduct of the current research or preparation of the manuscript. Funding Information: information National Science Foundation, Grant/Award Number: NSF 1449440; Price Foundation of Geneva, Switzerland; Military Suicide Research Consortium, U.S. Department of Defense, Grant/Award Numbers: W81XWH-10-2-0181, W81XWH-16-2-0003; Vetenskapsr{\aa}det, Grant/Award Number: VR Dnr: 538-2013-8864; Swedish Research Council, Grant/Award Number: VR Dnr: 538-2013-8864This material is based upon work supported by the National Science Foundation Graduate Research Fellowship Program under Grant No. NSF 1449440. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the National Science Foundation. This project was also in part supported by the Military Suicide Research Consortium (MSRC), an effort supported by the Department of Defense (W81XWH-10-2-0181; W81XWH-16-2-0003). Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the Military Suicide Research Consortium or the Department of Defense. This work was also financially supported by the Price Foundation of Geneva, Switzerland. Dr. Bulik acknowledges funding from the Swedish Research Council (VR Dnr: 538-2013-8864). The funding sources had no role in the conduct of the current research or preparation of the manuscript. Funding Information: National Science Foundation, Grant/Award Number: NSF 1449440; Price Foundation of Geneva, Switzerland; Military Suicide Research Consortium, U.S. Department of Defense, Grant/Award Numbers: W81XWH-10-2-0181, W81XWH-16-2-0003; Vetenskapsr{\aa}det, Grant/Award Number: VR Dnr: 538-2013-8864; Swedish Research Council, Grant/Award Number: VR Dnr: 538-2013-8864 Publisher Copyright: {\textcopyright} 2019 Wiley Periodicals, Inc.",

year = "2019",

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doi = "10.1002/eat.23008",

language = "English (US)",

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Duffy, ME, Rogers, ML, Joiner, TE, Bergen, AW, Berrettini, W, Bulik, CM, Brandt, H, Crawford, S, Crow, S, Fichter, M, Halmi, K, Kaplan, AS, Klump, KL, Lilenfeld, L, Magistretti, PJ, Mitchell, J, Schork, NJ, Strober, M, Thornton, LM, Treasure, J, Woodside, B, Kaye, WH & Keel, PK 2019, 'An investigation of indirect effects of personality features on anorexia nervosa severity through interoceptive dysfunction in individuals with lifetime anorexia nervosa diagnoses', International Journal of Eating Disorders, vol. 52, no. 2, pp. 200-205. https://doi.org/10.1002/eat.23008

An investigation of indirect effects of personality features on anorexia nervosa severity through interoceptive dysfunction in individuals with lifetime anorexia nervosa diagnoses. / Duffy, Mary E.; Rogers, Megan L.; Joiner, Thomas E. et al.
In: International Journal of Eating Disorders, Vol. 52, No. 2, 02.2019, p. 200-205.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - An investigation of indirect effects of personality features on anorexia nervosa severity through interoceptive dysfunction in individuals with lifetime anorexia nervosa diagnoses

AU - Duffy, Mary E.

AU - Rogers, Megan L.

AU - Joiner, Thomas E.

AU - Bergen, Andrew W.

AU - Berrettini, Wade

AU - Bulik, Cynthia M.

AU - Brandt, Harry

AU - Crawford, Steven

AU - Crow, Scott

AU - Fichter, Manfred

AU - Halmi, Katherine

AU - Kaplan, Allan S.

AU - Klump, Kelly L.

AU - Lilenfeld, Lisa

AU - Magistretti, Pierre J.

AU - Mitchell, James

AU - Schork, Nicholas J.

AU - Strober, Michael

AU - Thornton, Laura M.

AU - Treasure, Janet

AU - Woodside, Blake

AU - Kaye, Walter H.

AU - Keel, Pamela K.

N1 - Funding Information: This material is based upon work supported by the National Science Foundation Graduate Research Fellowship Program under Grant No. NSF 1449440. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the National Science Foundation. This project was also in part supported by the Military Suicide Research Consortium (MSRC), an effort supported by the Department of Defense (W81XWH-10-2-0181; W81XWH-16-2-0003). Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the Military Suicide Research Consortium or the Department of Defense. This work was also financially supported by the Price Foundation of Geneva, Switzerland. Dr. Bulik acknowledges funding from the Swedish Research Council (VR Dnr: 538-2013-8864). The funding sources had no role in the conduct of the current research or preparation of the manuscript. Funding Information: information National Science Foundation, Grant/Award Number: NSF 1449440; Price Foundation of Geneva, Switzerland; Military Suicide Research Consortium, U.S. Department of Defense, Grant/Award Numbers: W81XWH-10-2-0181, W81XWH-16-2-0003; Vetenskapsrådet, Grant/Award Number: VR Dnr: 538-2013-8864; Swedish Research Council, Grant/Award Number: VR Dnr: 538-2013-8864This material is based upon work supported by the National Science Foundation Graduate Research Fellowship Program under Grant No. NSF 1449440. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the National Science Foundation. This project was also in part supported by the Military Suicide Research Consortium (MSRC), an effort supported by the Department of Defense (W81XWH-10-2-0181; W81XWH-16-2-0003). Opinions, interpretations, conclusions, and recommendations are those of the authors and are not necessarily endorsed by the Military Suicide Research Consortium or the Department of Defense. This work was also financially supported by the Price Foundation of Geneva, Switzerland. Dr. Bulik acknowledges funding from the Swedish Research Council (VR Dnr: 538-2013-8864). The funding sources had no role in the conduct of the current research or preparation of the manuscript. Funding Information: National Science Foundation, Grant/Award Number: NSF 1449440; Price Foundation of Geneva, Switzerland; Military Suicide Research Consortium, U.S. Department of Defense, Grant/Award Numbers: W81XWH-10-2-0181, W81XWH-16-2-0003; Vetenskapsrådet, Grant/Award Number: VR Dnr: 538-2013-8864; Swedish Research Council, Grant/Award Number: VR Dnr: 538-2013-8864 Publisher Copyright: © 2019 Wiley Periodicals, Inc.

PY - 2019/2

Y1 - 2019/2

N2 - Objective: This study examined a hypothesized pathway by which interoceptive dysfunction accounted for associations between personality features (harm avoidance, self-directedness, and perfectionism) and anorexia nervosa (AN) severity (indicated by drive for thinness, eating disorder-related preoccupations and rituals, and body mass index). Method: The study sample (n = 270, mean age = 28.47, 95.2% female, 98% White/Caucasian) consisted of probands and biological relatives who met DSM-IV criteria for lifetime diagnoses of AN (omitting criterion D, amenorrhea) drawn from the Price Foundation Anorexia Nervosa Affected Relative Pairs Study (AN-ARP). Participants completed measures assessing personality, interoceptive dysfunction, and eating pathology. Results: Associations between personality features of low self-directedness and high perfectionism and indicators of AN severity (drive for thinness and eating disorder-related preoccupations and rituals) were significant, as were the hypothesized indirect pathways through interoceptive dysfunction. Neither harm avoidance nor body mass index was significantly related to other study variables, and the proposed indirect pathways involving these variables were not significant. Discussion: Findings suggest that certain personality features may relate to AN severity, in part, through their associations with interoceptive dysfunction. Future research should examine prospective associations and the value of interventions targeting interoceptive dysfunction for interrupting the link between personality and AN severity.

AB - Objective: This study examined a hypothesized pathway by which interoceptive dysfunction accounted for associations between personality features (harm avoidance, self-directedness, and perfectionism) and anorexia nervosa (AN) severity (indicated by drive for thinness, eating disorder-related preoccupations and rituals, and body mass index). Method: The study sample (n = 270, mean age = 28.47, 95.2% female, 98% White/Caucasian) consisted of probands and biological relatives who met DSM-IV criteria for lifetime diagnoses of AN (omitting criterion D, amenorrhea) drawn from the Price Foundation Anorexia Nervosa Affected Relative Pairs Study (AN-ARP). Participants completed measures assessing personality, interoceptive dysfunction, and eating pathology. Results: Associations between personality features of low self-directedness and high perfectionism and indicators of AN severity (drive for thinness and eating disorder-related preoccupations and rituals) were significant, as were the hypothesized indirect pathways through interoceptive dysfunction. Neither harm avoidance nor body mass index was significantly related to other study variables, and the proposed indirect pathways involving these variables were not significant. Discussion: Findings suggest that certain personality features may relate to AN severity, in part, through their associations with interoceptive dysfunction. Future research should examine prospective associations and the value of interventions targeting interoceptive dysfunction for interrupting the link between personality and AN severity.

KW - anorexia nervosa

KW - body mass index

KW - feeding and eating disorders

KW - perfectionism

KW - personality

KW - thinness

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DO - 10.1002/eat.23008

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SN - 0276-3478

VL - 52

SP - 200

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JO - International Journal of Eating Disorders

JF - International Journal of Eating Disorders

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ER -

An investigation of indirect effects of personality features on anorexia nervosa severity through interoceptive dysfunction in individuals with lifetime anorexia nervosa diagnoses

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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