Abstract
A thorough study on copper-free Sonogashira cross-couplings in water was carried out using the palla-dacycle, [{Pd(μ-Cl){K2-P,C-P(iPr) 2(OC6H3-2-Ph)}}2] as pre-catalyst with different bases and palladium concentrations. The highly active pre-catalyst imparts good to near quantitative yields using a concentration of 0.25 mol % at 40 °C. This broadly applicable protocol exhibits high tolerance of functional groups and substitution patterns. © 2011 Elsevier Ltd. All rights reserved.
Original language | English (US) |
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Pages (from-to) | 6355-6358 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 52 |
Issue number | 48 |
DOIs | |
State | Published - Nov 2011 |
Bibliographical note
KAUST Repository Item: Exported on 2020-10-01Acknowledgements: We are grateful to KAUST (baseline funding J.E., graduate fellowship for A.N.M.) for funding of this project.
ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry
- Drug Discovery