Amorphous Conjugated Polymers as Efficient Dual-Mode MALDI Matrices for Low-Molecular-Weight Analytes

Kilian Horatz, Kristina Ditte, Thomas Prenveille, Ke Nan Zhang, Dieter Jehnichen, Anton Kiriy, Brigitte Voit, Franziska Lissel

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS) usually employs highly crystalline small-molecule matrices, and the analyte is interpreted as being co-crystallized with the matrix. We recently showed that semi-crystalline polymers are efficient matrices for the detection of low-molecular-weight compounds (LMWCs) in MALDI MS and MALDI MS Imaging, and are dual-mode, i. e., enabling both positive and negative modes. The matrix performances of two fluorene/napthalene diimide co-polymers P(TNDIT-Fl(C4C2)) and P(TNDIT-Fl(C10C8)) were investigated and compared. Both are fully amorphous according to XRD measurements, show high relative absorption values at the wavelength of common MALDI lasers (λNd:YAG=355 nm: C4C2=73 %; C10C8=67 %), and are solution processable. As matrices, they are dual-mode, and enable the detection of LMWCs while being mostly MALDI-silent. Compared with semicrystalline polymer matrices, the amorphous matrices give similar or better signal intensities, thus indicating that analyte inclusion takes place in the amorphous part of the polymer matrix.
Original languageEnglish (US)
Pages (from-to)1338-1345
Number of pages8
Issue number9
StatePublished - Jun 18 2019
Externally publishedYes

Bibliographical note

KAUST Repository Item: Exported on 2022-06-10
Acknowledged KAUST grant number(s): OSR-2017-CPF-3322-01
Acknowledgements: F.L. thanks the FCI for a Liebig Fellowship. K.-N.Z. gratefully acknowledges a scholarship under the Chinese State Scholarship Fund for outstanding students abroad by the China Scholarship Council (CSC). The work was in part supported by KAUST Center Partnership Fund OSR-2017-CPF-3322-01.
This publication acknowledges KAUST support, but has no KAUST affiliated authors.

ASJC Scopus subject areas

  • General Chemistry


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