Amorphous Conjugated Polymers as Efficient Dual-Mode MALDI Matrices for Low-Molecular-Weight Analytes

Kilian Horatz; Kristina Ditte; Thomas Prenveille; Ke Nan Zhang; Dieter Jehnichen; Anton Kiriy; Brigitte Voit; Franziska Lissel

doi:10.1002/cplu.201900203

Amorphous Conjugated Polymers as Efficient Dual-Mode MALDI Matrices for Low-Molecular-Weight Analytes

Kilian Horatz, Kristina Ditte, Thomas Prenveille, Ke Nan Zhang, Dieter Jehnichen, Anton Kiriy, Brigitte Voit, Franziska Lissel

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS) usually employs highly crystalline small-molecule matrices, and the analyte is interpreted as being co-crystallized with the matrix. We recently showed that semi-crystalline polymers are efficient matrices for the detection of low-molecular-weight compounds (LMWCs) in MALDI MS and MALDI MS Imaging, and are dual-mode, i. e., enabling both positive and negative modes. The matrix performances of two fluorene/napthalene diimide co-polymers P(TNDIT-Fl(C4C2)) and P(TNDIT-Fl(C10C8)) were investigated and compared. Both are fully amorphous according to XRD measurements, show high relative absorption values at the wavelength of common MALDI lasers (λNd:YAG=355 nm: C4C2=73 %; C10C8=67 %), and are solution processable. As matrices, they are dual-mode, and enable the detection of LMWCs while being mostly MALDI-silent. Compared with semicrystalline polymer matrices, the amorphous matrices give similar or better signal intensities, thus indicating that analyte inclusion takes place in the amorphous part of the polymer matrix.

Original language	English (US)
Pages (from-to)	1338-1345
Number of pages	8
Journal	ChemPlusChem
Volume	84
Issue number	9
DOIs	https://doi.org/10.1002/cplu.201900203
State	Published - Jun 18 2019
Externally published	Yes

Bibliographical note

KAUST Repository Item: Exported on 2022-06-10
Acknowledged KAUST grant number(s): OSR-2017-CPF-3322-01
Acknowledgements: F.L. thanks the FCI for a Liebig Fellowship. K.-N.Z. gratefully acknowledges a scholarship under the Chinese State Scholarship Fund for outstanding students abroad by the China Scholarship Council (CSC). The work was in part supported by KAUST Center Partnership Fund OSR-2017-CPF-3322-01.
This publication acknowledges KAUST support, but has no KAUST affiliated authors.

ASJC Scopus subject areas

General Chemistry

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10.1002/cplu.201900203

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title = "Amorphous Conjugated Polymers as Efficient Dual-Mode MALDI Matrices for Low-Molecular-Weight Analytes",

abstract = "Matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS) usually employs highly crystalline small-molecule matrices, and the analyte is interpreted as being co-crystallized with the matrix. We recently showed that semi-crystalline polymers are efficient matrices for the detection of low-molecular-weight compounds (LMWCs) in MALDI MS and MALDI MS Imaging, and are dual-mode, i. e., enabling both positive and negative modes. The matrix performances of two fluorene/napthalene diimide co-polymers P(TNDIT-Fl(C4C2)) and P(TNDIT-Fl(C10C8)) were investigated and compared. Both are fully amorphous according to XRD measurements, show high relative absorption values at the wavelength of common MALDI lasers (λNd:YAG=355 nm: C4C2=73 %; C10C8=67 %), and are solution processable. As matrices, they are dual-mode, and enable the detection of LMWCs while being mostly MALDI-silent. Compared with semicrystalline polymer matrices, the amorphous matrices give similar or better signal intensities, thus indicating that analyte inclusion takes place in the amorphous part of the polymer matrix.",

author = "Kilian Horatz and Kristina Ditte and Thomas Prenveille and Zhang, {Ke Nan} and Dieter Jehnichen and Anton Kiriy and Brigitte Voit and Franziska Lissel",

note = "KAUST Repository Item: Exported on 2022-06-10 Acknowledged KAUST grant number(s): OSR-2017-CPF-3322-01 Acknowledgements: F.L. thanks the FCI for a Liebig Fellowship. K.-N.Z. gratefully acknowledges a scholarship under the Chinese State Scholarship Fund for outstanding students abroad by the China Scholarship Council (CSC). The work was in part supported by KAUST Center Partnership Fund OSR-2017-CPF-3322-01. This publication acknowledges KAUST support, but has no KAUST affiliated authors.",

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AU - Jehnichen, Dieter

AU - Kiriy, Anton

AU - Voit, Brigitte

AU - Lissel, Franziska

N1 - KAUST Repository Item: Exported on 2022-06-10 Acknowledged KAUST grant number(s): OSR-2017-CPF-3322-01 Acknowledgements: F.L. thanks the FCI for a Liebig Fellowship. K.-N.Z. gratefully acknowledges a scholarship under the Chinese State Scholarship Fund for outstanding students abroad by the China Scholarship Council (CSC). The work was in part supported by KAUST Center Partnership Fund OSR-2017-CPF-3322-01. This publication acknowledges KAUST support, but has no KAUST affiliated authors.

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N2 - Matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS) usually employs highly crystalline small-molecule matrices, and the analyte is interpreted as being co-crystallized with the matrix. We recently showed that semi-crystalline polymers are efficient matrices for the detection of low-molecular-weight compounds (LMWCs) in MALDI MS and MALDI MS Imaging, and are dual-mode, i. e., enabling both positive and negative modes. The matrix performances of two fluorene/napthalene diimide co-polymers P(TNDIT-Fl(C4C2)) and P(TNDIT-Fl(C10C8)) were investigated and compared. Both are fully amorphous according to XRD measurements, show high relative absorption values at the wavelength of common MALDI lasers (λNd:YAG=355 nm: C4C2=73 %; C10C8=67 %), and are solution processable. As matrices, they are dual-mode, and enable the detection of LMWCs while being mostly MALDI-silent. Compared with semicrystalline polymer matrices, the amorphous matrices give similar or better signal intensities, thus indicating that analyte inclusion takes place in the amorphous part of the polymer matrix.

AB - Matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS) usually employs highly crystalline small-molecule matrices, and the analyte is interpreted as being co-crystallized with the matrix. We recently showed that semi-crystalline polymers are efficient matrices for the detection of low-molecular-weight compounds (LMWCs) in MALDI MS and MALDI MS Imaging, and are dual-mode, i. e., enabling both positive and negative modes. The matrix performances of two fluorene/napthalene diimide co-polymers P(TNDIT-Fl(C4C2)) and P(TNDIT-Fl(C10C8)) were investigated and compared. Both are fully amorphous according to XRD measurements, show high relative absorption values at the wavelength of common MALDI lasers (λNd:YAG=355 nm: C4C2=73 %; C10C8=67 %), and are solution processable. As matrices, they are dual-mode, and enable the detection of LMWCs while being mostly MALDI-silent. Compared with semicrystalline polymer matrices, the amorphous matrices give similar or better signal intensities, thus indicating that analyte inclusion takes place in the amorphous part of the polymer matrix.

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Amorphous Conjugated Polymers as Efficient Dual-Mode MALDI Matrices for Low-Molecular-Weight Analytes

Abstract

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