Amorphous Conjugated Polymers as Efficient Dual-Mode MALDI Matrices for Low-Molecular-Weight Analytes

Kilian Horatz, Kristina Ditte, Thomas Prenveille, Ke Nan Zhang, Dieter Jehnichen, Anton Kiriy, Brigitte Voit, Franziska Lissel

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS) usually employs highly crystalline small-molecule matrices, and the analyte is interpreted as being co-crystallized with the matrix. We recently showed that semi-crystalline polymers are efficient matrices for the detection of low-molecular-weight compounds (LMWCs) in MALDI MS and MALDI MS Imaging, and are dual-mode, i. e., enabling both positive and negative modes. The matrix performances of two fluorene/napthalene diimide co-polymers P(TNDIT-Fl(C4C2)) and P(TNDIT-Fl(C10C8)) were investigated and compared. Both are fully amorphous according to XRD measurements, show high relative absorption values at the wavelength of common MALDI lasers (λNd:YAG=355 nm: C4C2=73 %; C10C8=67 %), and are solution processable. As matrices, they are dual-mode, and enable the detection of LMWCs while being mostly MALDI-silent. Compared with semicrystalline polymer matrices, the amorphous matrices give similar or better signal intensities, thus indicating that analyte inclusion takes place in the amorphous part of the polymer matrix.
Original languageEnglish (US)
Pages (from-to)1338-1345
Number of pages8
JournalChemPlusChem
Volume84
Issue number9
DOIs
StatePublished - Jun 18 2019
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)

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