Alleviating mass transfer limitations in industrial external-loop syngas-to-ethanol fermentation

Mass transfer limitations in syngas fermentation processes are mostly attributed to poor solubility of CO and H2 in water. Despite these assumed limitations, a syngas fermentation process has recently been commercialized. Using large-sale external-loop gas-lift reactors (EL-GLR), CO-rich off-gases are converted into ethanol, with high mass transfer performance (7–8.5 g.L-1.h−1). However, when applying established mass transfer correlations, a much poorer performance is predicted (0.3–2.7 g.L-1.h−1). We developed a CFD model, validated on pilot-scale data, to provide detailed insights on hydrodynamics and mass transfer in a large-scale EL-GLR. As produced ethanol could increase gas hold-up (+30%) and decrease the bubble diameter (≤2 mm) compared to air–water mixtures, we found with our model that a high volumetric mass transfer coefficient (650–750 h−1) and mass transfer capacity (7.5–8 g.L-1.h−1) for CO are feasible. Thus, the typical mass transfer limitations encountered in air–water systems can be alleviated in the syngas-to-ethanol fermentation process.