Abstract
Background: Reference intervals can vary based on age and gender. Proper partitioning is necessary to classify health status in different age groups. Methods: Seven analytes; aldolase, amylase, ceruloplasmin, creatine kinase, pancreatic amylase, prealbumin and uric acid; were assayed on Roche Modular P analyzers using serum samples from 1765 children (867 females and 898 males; age range, 6. months to 17. y). Subjects 6. months up to 7. y were undergoing minor surgical procedures. Children 7 to 17. y were apparently healthy. Subjects with significant medical history or who were taking any medications were excluded. Results: Separate reference intervals for boys and girls were required for 33% of the groups. Aldolase showed gender variation in the 6-8, 12-14, and 15-17. y. Amylase was the only analyte that showed no significant gender differences within any age group. Both ceruloplasmin and uric acid had significant differences between the 12-14 and 15-17. y groups. Creatine kinase exhibited statistically significant gender differences in all age groups with the exception of 6-8. y. Conclusion: We verified that when establishing pediatric reference intervals, partitioning by age and gender is frequently necessary. © 2011 Elsevier B.V.
Original language | English (US) |
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Pages (from-to) | 788-790 |
Number of pages | 3 |
Journal | Clinica Chimica Acta |
Volume | 412 |
Issue number | 9-10 |
DOIs | |
State | Published - Apr 11 2011 |
Externally published | Yes |
Bibliographical note
Generated from Scopus record by KAUST IRTS on 2023-09-20ASJC Scopus subject areas
- Biochemistry
- Clinical Biochemistry
- Biochemistry, medical