Abstract
We reported herein new reactivities and possible mechanistic implications of a simplest oxidant (NaH/air) uncovered on a broad range of useful transformations, including aerobic alcohol oxidations, allylic alcohol isomerizations and oxidations, cyclopropyl alcohol fragmentations, and direct aryl aldehyde oxidative amidations. These readily implementable transition-metal-free processes feature exceptional material accessibility, operational simplicity, and environmental compatibility, and add new dimensions to its synthetic utilities that are fairly robust yet had not previously been fully realized and systematically explored.
Original language | English (US) |
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Pages (from-to) | 3406-3411 |
Number of pages | 6 |
Journal | Tetrahedron |
Volume | 67 |
Issue number | 19 |
DOIs | |
State | Published - May 13 2011 |
Externally published | Yes |
Keywords
- Aerobic oxidation
- Benzylic alcohol
- Oxidative amidation
- Sodium hydride
- Sodium hydrogen peroxide
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry