Advancing Transdermal Therapeutics: In-Vivo Assessment and Computational Insights into Porous Microneedle-Based Drug Delivery

Esraa Fakeih; Dana Al Sulaiman; Khaled Nabil Salama

doi:10.1109/SENSORS56945.2023.10325189

Advancing Transdermal Therapeutics: In-Vivo Assessment and Computational Insights into Porous Microneedle-Based Drug Delivery

Esraa Fakeih, Dana Al Sulaiman, Khaled Nabil Salama

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Porous microneedles (MN) offer the advantage of allowing for higher dosage delivery because of their larger surface area and broader diffusion spread compared to topical delivery. In this study, porous MNs were fabricated using two-photon polymerization. We simulated the diffusion of fluorescein isothiocyanate (FITC)-dextran as a pseudo drug through the skin with and without the porous MN and proved that at a depth of 100?m in the dermis, the porous MN delivers over 4 times the concentration of FITC-dextran compared to topical delivery. We also performed an in vivo study on mouse skin by delivering a fast green FCF stain through a 5 × 5 array of porous MNs. The dye was successfully delivered, and the array remained intact after insertion.

Original language	English (US)
Title of host publication	2023 IEEE SENSORS, SENSORS 2023 - Conference Proceedings
Publisher	Institute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)	9798350303872
DOIs	https://doi.org/10.1109/SENSORS56945.2023.10325189
State	Published - 2023
Event	2023 IEEE SENSORS, SENSORS 2023 - Vienna, Austria Duration: Oct 29 2023 → Nov 1 2023

Publication series

Name	Proceedings of IEEE Sensors
ISSN (Print)	1930-0395
ISSN (Electronic)	2168-9229

Conference

Conference	2023 IEEE SENSORS, SENSORS 2023
Country/Territory	Austria
City	Vienna
Period	10/29/23 → 11/1/23

Bibliographical note

Publisher Copyright:
© 2023 IEEE.

Keywords

drug delivery
in-vivo
microneedles
simulation

ASJC Scopus subject areas

Electrical and Electronic Engineering

Access to Document

10.1109/SENSORS56945.2023.10325189

Cite this

Fakeih, E., Al Sulaiman, D., & Salama, K. N. (2023). Advancing Transdermal Therapeutics: In-Vivo Assessment and Computational Insights into Porous Microneedle-Based Drug Delivery. In 2023 IEEE SENSORS, SENSORS 2023 - Conference Proceedings (Proceedings of IEEE Sensors). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/SENSORS56945.2023.10325189

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title = "Advancing Transdermal Therapeutics: In-Vivo Assessment and Computational Insights into Porous Microneedle-Based Drug Delivery",

abstract = "Porous microneedles (MN) offer the advantage of allowing for higher dosage delivery because of their larger surface area and broader diffusion spread compared to topical delivery. In this study, porous MNs were fabricated using two-photon polymerization. We simulated the diffusion of fluorescein isothiocyanate (FITC)-dextran as a pseudo drug through the skin with and without the porous MN and proved that at a depth of 100?m in the dermis, the porous MN delivers over 4 times the concentration of FITC-dextran compared to topical delivery. We also performed an in vivo study on mouse skin by delivering a fast green FCF stain through a 5 × 5 array of porous MNs. The dye was successfully delivered, and the array remained intact after insertion.",

keywords = "drug delivery, in-vivo, microneedles, simulation",

author = "Esraa Fakeih and {Al Sulaiman}, Dana and Salama, {Khaled Nabil}",

note = "Publisher Copyright: {\textcopyright} 2023 IEEE.; 2023 IEEE SENSORS, SENSORS 2023 ; Conference date: 29-10-2023 Through 01-11-2023",

year = "2023",

doi = "10.1109/SENSORS56945.2023.10325189",

language = "English (US)",

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Fakeih, E , Al Sulaiman, D & Salama, KN 2023, Advancing Transdermal Therapeutics: In-Vivo Assessment and Computational Insights into Porous Microneedle-Based Drug Delivery. in 2023 IEEE SENSORS, SENSORS 2023 - Conference Proceedings. Proceedings of IEEE Sensors, Institute of Electrical and Electronics Engineers Inc., 2023 IEEE SENSORS, SENSORS 2023, Vienna, Austria, 10/29/23. https://doi.org/10.1109/SENSORS56945.2023.10325189

Advancing Transdermal Therapeutics: In-Vivo Assessment and Computational Insights into Porous Microneedle-Based Drug Delivery. / Fakeih, Esraa ; Al Sulaiman, Dana ; Salama, Khaled Nabil.
2023 IEEE SENSORS, SENSORS 2023 - Conference Proceedings. Institute of Electrical and Electronics Engineers Inc., 2023. (Proceedings of IEEE Sensors).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AU - Al Sulaiman, Dana

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N2 - Porous microneedles (MN) offer the advantage of allowing for higher dosage delivery because of their larger surface area and broader diffusion spread compared to topical delivery. In this study, porous MNs were fabricated using two-photon polymerization. We simulated the diffusion of fluorescein isothiocyanate (FITC)-dextran as a pseudo drug through the skin with and without the porous MN and proved that at a depth of 100?m in the dermis, the porous MN delivers over 4 times the concentration of FITC-dextran compared to topical delivery. We also performed an in vivo study on mouse skin by delivering a fast green FCF stain through a 5 × 5 array of porous MNs. The dye was successfully delivered, and the array remained intact after insertion.

AB - Porous microneedles (MN) offer the advantage of allowing for higher dosage delivery because of their larger surface area and broader diffusion spread compared to topical delivery. In this study, porous MNs were fabricated using two-photon polymerization. We simulated the diffusion of fluorescein isothiocyanate (FITC)-dextran as a pseudo drug through the skin with and without the porous MN and proved that at a depth of 100?m in the dermis, the porous MN delivers over 4 times the concentration of FITC-dextran compared to topical delivery. We also performed an in vivo study on mouse skin by delivering a fast green FCF stain through a 5 × 5 array of porous MNs. The dye was successfully delivered, and the array remained intact after insertion.

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Advancing Transdermal Therapeutics: In-Vivo Assessment and Computational Insights into Porous Microneedle-Based Drug Delivery

Abstract

Publication series

Conference

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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