TY - JOUR
T1 - Advancement in the treatment of haemophilia
AU - Bhardwaj, Rahul
AU - Rath, Goutam
AU - Goyal, Amit K.
N1 - Generated from Scopus record by KAUST IRTS on 2023-10-12
PY - 2018/10/15
Y1 - 2018/10/15
N2 - Poor understanding of the pathophysiological mechanisms involved in Haemophilia is a major obstacle in accessing effective haemophilia disease management. Haemophilia is a life-frightening bleeding problem in which there are repeated bleeding episodes. Various approaches have been used, involves clotting factor replacement therapy for effective bleeding control in Haemophilia. Current advancements in the management of patients with haemophilia include altered pharmacokinetics clotting factor concentrates for better prophylaxis and management of haemophilia. This review sums up the prophylactic treatment, novel production techniques, other treatment techniques and the present position of gene therapy in the treatment of haemophilia.
AB - Poor understanding of the pathophysiological mechanisms involved in Haemophilia is a major obstacle in accessing effective haemophilia disease management. Haemophilia is a life-frightening bleeding problem in which there are repeated bleeding episodes. Various approaches have been used, involves clotting factor replacement therapy for effective bleeding control in Haemophilia. Current advancements in the management of patients with haemophilia include altered pharmacokinetics clotting factor concentrates for better prophylaxis and management of haemophilia. This review sums up the prophylactic treatment, novel production techniques, other treatment techniques and the present position of gene therapy in the treatment of haemophilia.
UR - https://linkinghub.elsevier.com/retrieve/pii/S0141813018324978
UR - http://www.scopus.com/inward/record.url?scp=85048857897&partnerID=8YFLogxK
U2 - 10.1016/j.ijbiomac.2018.06.084
DO - 10.1016/j.ijbiomac.2018.06.084
M3 - Article
SN - 1879-0003
VL - 118
SP - 289
EP - 295
JO - International Journal of Biological Macromolecules
JF - International Journal of Biological Macromolecules
ER -