Acute Changes in P-Wave Morphology by Pulmonary Vein Isolation in Atrial Fibrillation Patients

Ali Gharaviri; Matthias Zink; Mark Potse; Simone Pezzuto; Stef Zeemering; Rolf Krause; Angelo Auricchio; Ulrich Schotten

doi:10.22489/CinC.2018.034

Acute Changes in P-Wave Morphology by Pulmonary Vein Isolation in Atrial Fibrillation Patients

Ali Gharaviri^*, Matthias Zink, Mark Potse, Simone Pezzuto, Stef Zeemering, Rolf Krause, Angelo Auricchio, Ulrich Schotten

^*Corresponding author for this work

Applied Mathematics and Computational Science

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

2 Scopus citations

Abstract

Pulmonary vein (PV) plays an important role in atrial fibrillation (AF) initiation, progression, and stability. Successful PV isolation (PVI), either by radiofrequency catheter or Cryoballoon ablation, may terminate AF and prevent its recurrence. Whereas, incomplete PV isolation or reconnection of isolated PVs underlies mechanisms of AF recurrence. Hence, defining parameters able to predict a successful PVI and detect reconnections can assist clinicians in treatment of AF patients. Here, we developed a highly detailed human atrial model to simulate PVI and its acute effect on the P-wave morphology. Afterwards, the simulation results were compared and validated by recorded ECGs from patients before and after PVI procedure. In both simulation data and clinical recordings, we observed morphological changes in P-wave after PVI. More importantly our simulation helped us to find electrode positions, in which the differences in P-wave morphology before and after PVI were more pronounced.

Original language	English (US)
Title of host publication	Computing in Cardiology Conference, CinC 2018
Publisher	IEEE Computer Society
ISBN (Electronic)	9781728109589
DOIs	https://doi.org/10.22489/CinC.2018.034
State	Published - Sep 2018
Event	45th Computing in Cardiology Conference, CinC 2018 - Maastricht, Netherlands Duration: Sep 23 2018 → Sep 26 2018

Publication series

Name	Computing in Cardiology
Volume	2018-September
ISSN (Print)	2325-8861
ISSN (Electronic)	2325-887X

Conference

Conference	45th Computing in Cardiology Conference, CinC 2018
Country/Territory	Netherlands
City	Maastricht
Period	09/23/18 → 09/26/18

Bibliographical note

Publisher Copyright:
© 2018 Creative Commons Attribution.

ASJC Scopus subject areas

General Computer Science
Cardiology and Cardiovascular Medicine

Access to Document

10.22489/CinC.2018.034

Cite this

Gharaviri, A., Zink, M., Potse, M., Pezzuto, S., Zeemering, S., Krause, R., Auricchio, A., & Schotten, U. (2018). Acute Changes in P-Wave Morphology by Pulmonary Vein Isolation in Atrial Fibrillation Patients. In Computing in Cardiology Conference, CinC 2018 Article 8744057 (Computing in Cardiology; Vol. 2018-September). IEEE Computer Society. https://doi.org/10.22489/CinC.2018.034

@inproceedings{64c7cafb2b894a379759e1362d98d571,

title = "Acute Changes in P-Wave Morphology by Pulmonary Vein Isolation in Atrial Fibrillation Patients",

abstract = "Pulmonary vein (PV) plays an important role in atrial fibrillation (AF) initiation, progression, and stability. Successful PV isolation (PVI), either by radiofrequency catheter or Cryoballoon ablation, may terminate AF and prevent its recurrence. Whereas, incomplete PV isolation or reconnection of isolated PVs underlies mechanisms of AF recurrence. Hence, defining parameters able to predict a successful PVI and detect reconnections can assist clinicians in treatment of AF patients. Here, we developed a highly detailed human atrial model to simulate PVI and its acute effect on the P-wave morphology. Afterwards, the simulation results were compared and validated by recorded ECGs from patients before and after PVI procedure. In both simulation data and clinical recordings, we observed morphological changes in P-wave after PVI. More importantly our simulation helped us to find electrode positions, in which the differences in P-wave morphology before and after PVI were more pronounced.",

author = "Ali Gharaviri and Matthias Zink and Mark Potse and Simone Pezzuto and Stef Zeemering and Rolf Krause and Angelo Auricchio and Ulrich Schotten",

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year = "2018",

month = sep,

doi = "10.22489/CinC.2018.034",

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Gharaviri, A, Zink, M, Potse, M, Pezzuto, S, Zeemering, S, Krause, R, Auricchio, A & Schotten, U 2018, Acute Changes in P-Wave Morphology by Pulmonary Vein Isolation in Atrial Fibrillation Patients. in Computing in Cardiology Conference, CinC 2018., 8744057, Computing in Cardiology, vol. 2018-September, IEEE Computer Society, 45th Computing in Cardiology Conference, CinC 2018, Maastricht, Netherlands, 09/23/18. https://doi.org/10.22489/CinC.2018.034

Acute Changes in P-Wave Morphology by Pulmonary Vein Isolation in Atrial Fibrillation Patients. / Gharaviri, Ali; Zink, Matthias; Potse, Mark et al.
Computing in Cardiology Conference, CinC 2018. IEEE Computer Society, 2018. 8744057 (Computing in Cardiology; Vol. 2018-September).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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T1 - Acute Changes in P-Wave Morphology by Pulmonary Vein Isolation in Atrial Fibrillation Patients

AU - Gharaviri, Ali

AU - Zink, Matthias

AU - Potse, Mark

AU - Pezzuto, Simone

AU - Zeemering, Stef

AU - Krause, Rolf

AU - Auricchio, Angelo

AU - Schotten, Ulrich

PY - 2018/9

Y1 - 2018/9

N2 - Pulmonary vein (PV) plays an important role in atrial fibrillation (AF) initiation, progression, and stability. Successful PV isolation (PVI), either by radiofrequency catheter or Cryoballoon ablation, may terminate AF and prevent its recurrence. Whereas, incomplete PV isolation or reconnection of isolated PVs underlies mechanisms of AF recurrence. Hence, defining parameters able to predict a successful PVI and detect reconnections can assist clinicians in treatment of AF patients. Here, we developed a highly detailed human atrial model to simulate PVI and its acute effect on the P-wave morphology. Afterwards, the simulation results were compared and validated by recorded ECGs from patients before and after PVI procedure. In both simulation data and clinical recordings, we observed morphological changes in P-wave after PVI. More importantly our simulation helped us to find electrode positions, in which the differences in P-wave morphology before and after PVI were more pronounced.

AB - Pulmonary vein (PV) plays an important role in atrial fibrillation (AF) initiation, progression, and stability. Successful PV isolation (PVI), either by radiofrequency catheter or Cryoballoon ablation, may terminate AF and prevent its recurrence. Whereas, incomplete PV isolation or reconnection of isolated PVs underlies mechanisms of AF recurrence. Hence, defining parameters able to predict a successful PVI and detect reconnections can assist clinicians in treatment of AF patients. Here, we developed a highly detailed human atrial model to simulate PVI and its acute effect on the P-wave morphology. Afterwards, the simulation results were compared and validated by recorded ECGs from patients before and after PVI procedure. In both simulation data and clinical recordings, we observed morphological changes in P-wave after PVI. More importantly our simulation helped us to find electrode positions, in which the differences in P-wave morphology before and after PVI were more pronounced.

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M3 - Conference contribution

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PB - IEEE Computer Society

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Acute Changes in P-Wave Morphology by Pulmonary Vein Isolation in Atrial Fibrillation Patients

Abstract

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