A tightly-bonded and flexible mesoporous zeolite-cotton hybrid hemostat

Lisha Yu, Xiaoqiang Shang, Hao Chen, Liping Xiao, Yihan Zhu, Jie Fan

Research output: Contribution to journalArticlepeer-review

169 Scopus citations

Abstract

Achieving rapid definitive hemostasis is essential to ensure survival of patients with massive bleeding in pre-hospital care. It is however challenging to develop hemostatic agents or dressings that simultaneously deliver a fast, long-lasting and safe treatment of hemorrhage. Here, we integrate meso-/micro-porosity, blood coagulation and stability into a flexible zeolite-cotton hybrid hemostat. We employ an on-site template-free growth route that tightly binds mesoporous single-crystal chabazite zeolite onto the surface of cotton fibers. This hemostatic material maintains high procoagulant activity after water flow treatment. Chabazite particles are firmly anchored onto the cotton surface with < 1% leaching after 10 min of sonication. The as-synthesized hemostatic device has superior hemostatic performance over most other clay or zeolite-based inorganic hemostats, in terms of higher procoagulant activity, minimized loss of active components and better scalability for practical applications (a hemostatic T-shirt is hereby demonstrated as an example).
Original languageEnglish (US)
JournalNATURE COMMUNICATIONS
Volume10
Issue number1
DOIs
StatePublished - Apr 29 2019
Externally publishedYes

Bibliographical note

KAUST Repository Item: Exported on 2022-06-07
Acknowledgements: This work was supported by National Natural Science Foundation of China (91545113, 91845203), China Postdoctoral Science Foundation (2017M610363, 2018T110584), Shell Global Solutions International B. V. (PT71423, PT74557), Fok Ying Tong Education Foundation (131015), and the Science &amp; Technology Program of Ningbo (2017C50014). Y. Zhu acknowledges the financial support from the National Natural Science Foundation of China (Grant no. 21771161), the Thousand Talents Program for Distinguished Young Scholars and KAUST Visiting Researcher Scholar. We thank Dr. Zhangxiong Wu for for helpful discussion.
This publication acknowledges KAUST support, but has no KAUST affiliated authors.

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology
  • General Chemistry
  • General Physics and Astronomy

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