A sequence homology between the pX genes of HTLV-I/II and the murine IL-3 gene

Takashi Gojobori*, Shin ichi Aota, Tadashi Inoue, Kunitada Shimotohno

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Searching the protein sequence database for amino acid sequences homologous to the x-lor sequence in the pX region of human T-cell leukemia virus types I and II (HTLV-I/II), we found that there is a region of 38 amino acids where the murine interleukin 3 (IL-3) sequence has a 40% homology with the x-lor sequence. A statistical analysis shows that this homology is highly significant with a probability of 1.57 × 10-10. The biological implication of this homology is discussed.

Original languageEnglish (US)
Pages (from-to)231-235
Number of pages5
JournalFEBS Letters
Issue number2
StatePublished - Nov 24 1986
Externally publishedYes

Bibliographical note

Funding Information:
was supported by a Grant-in-Aid from the Ministry of Education, Science and Culture of Japan to T.G., T.I. and K.S., and NIH grant GM-28672 and NIMH grant MH-31302 to Dr Shozo Yokoyama.


  • HTLV-I HLTV-II pX gene x-lor gene Interleukin 3 Sequence homology Leukemogenesis Oncogene

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Biophysics
  • Structural Biology
  • Biochemistry
  • Cell Biology


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