Searching the protein sequence database for amino acid sequences homologous to the x-lor sequence in the pX region of human T-cell leukemia virus types I and II (HTLV-I/II), we found that there is a region of 38 amino acids where the murine interleukin 3 (IL-3) sequence has a 40% homology with the x-lor sequence. A statistical analysis shows that this homology is highly significant with a probability of 1.57 × 10-10. The biological implication of this homology is discussed.
Bibliographical noteFunding Information:
was supported by a Grant-in-Aid from the Ministry of Education, Science and Culture of Japan to T.G., T.I. and K.S., and NIH grant GM-28672 and NIMH grant MH-31302 to Dr Shozo Yokoyama.
- HTLV-I HLTV-II pX gene x-lor gene Interleukin 3 Sequence homology Leukemogenesis Oncogene
ASJC Scopus subject areas
- Molecular Biology
- Structural Biology
- Cell Biology