A rapid and convergent synthesis of the integrastatin core

Pamela M. Tadross, Pradeep Bugga, Brian M. Stoltz

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


The tetracyclic core of the integrastatin natural products has been prepared in a convergent and rapid manner. Our strategy relies upon a palladium(ii)-catalyzed oxidative cyclization to form the central [3.3.1]-dioxabicycle of the natural product core. Overall, the core has been completed in only 4 linear steps from known compounds. © 2011 The Royal Society of Chemistry.
Original languageEnglish (US)
Pages (from-to)5354
JournalOrganic & Biomolecular Chemistry
Issue number15
StatePublished - 2011
Externally publishedYes

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledged KAUST grant number(s): KUS-11-006-02
Acknowledgements: This publication is based on work supported by Award No. KUS-11-006-02, made by King Abdullah University of Science and Technology (KAUST). Financial support from Caltech, the Rose Hills Foundation (undergraduate fellowship to P.B.), and the California HIV/AIDS Research Program (graduate fellowship to P.M.T.) is also gratefully acknowledged.
This publication acknowledges KAUST support, but has no KAUST affiliated authors.


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