A rapid and convergent synthesis of the integrastatin core

Pamela M. Tadross; Pradeep Bugga; Brian M. Stoltz

doi:10.1039/c1ob05725a

A rapid and convergent synthesis of the integrastatin core

Pamela M. Tadross, Pradeep Bugga, Brian M. Stoltz

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

The tetracyclic core of the integrastatin natural products has been prepared in a convergent and rapid manner. Our strategy relies upon a palladium(ii)-catalyzed oxidative cyclization to form the central [3.3.1]-dioxabicycle of the natural product core. Overall, the core has been completed in only 4 linear steps from known compounds. © 2011 The Royal Society of Chemistry.

Original language	English (US)
Pages (from-to)	5354
Journal	Organic & Biomolecular Chemistry
Volume	9
Issue number	15
DOIs	https://doi.org/10.1039/c1ob05725a
State	Published - 2011
Externally published	Yes

Bibliographical note

KAUST Repository Item: Exported on 2020-10-01
Acknowledged KAUST grant number(s): KUS-11-006-02
Acknowledgements: This publication is based on work supported by Award No. KUS-11-006-02, made by King Abdullah University of Science and Technology (KAUST). Financial support from Caltech, the Rose Hills Foundation (undergraduate fellowship to P.B.), and the California HIV/AIDS Research Program (graduate fellowship to P.M.T.) is also gratefully acknowledged.
This publication acknowledges KAUST support, but has no KAUST affiliated authors.

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10.1039/c1ob05725a

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abstract = "The tetracyclic core of the integrastatin natural products has been prepared in a convergent and rapid manner. Our strategy relies upon a palladium(ii)-catalyzed oxidative cyclization to form the central [3.3.1]-dioxabicycle of the natural product core. Overall, the core has been completed in only 4 linear steps from known compounds. {\textcopyright} 2011 The Royal Society of Chemistry.",

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AU - Bugga, Pradeep

AU - Stoltz, Brian M.

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A rapid and convergent synthesis of the integrastatin core

Abstract

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